布地奈德联合利多卡因治疗对小儿急性喉炎临床效果、炎症因子及不良反应分析

Clinical Effect,Inflammatory Factors and Adverse Reactions of Budesonide Combined with Lidocaine in Children with Acute Laryngitis

目的:分析布地奈德联合利多卡因治疗对小儿急性喉炎临床效果、炎症因子及不良反应的影响。方法:选取2011年7月-2017年12月本院118例急性喉炎患儿,随机数字表法分为观察组(n=59)与对照组(n=59)。对照组单独予以布地奈德治疗,观察组予以布地奈德+利多卡因治疗。观察对比2组治疗效果、症状改善情况、不良反应发生率及治疗前后炎症因子[白细胞介素-8(IL-8)、γ-干扰素(IFN-γ)、C-反应蛋白(CRP)及肿瘤坏死因子-α(TNF-α)]水平。结果:观察组总有效率96.61%高于对照组84.75%(P<0.05);治疗5d后,观察组症状改善时间及住院天数均短于对照组(P<0.05);治疗5d后,观察组血清IL-8、IFN-γ、CRP、TNF-α水平低于对照组(P<0.05);2组不良反应发生率无显著差异(P>0.05)。结论:布地奈德联合利多卡因治疗小儿急性喉炎,疗效显著,可有效缩短临床症状改善时间,减轻炎症因子水平,不良反应少,安全性较高。

Objective:To analyze the effects of budesonide combined with lidocaine on clinical effects,inflammatory factors and adverse reactions in children with acute laryngitis.Method:A total of 118 children with acute laryngitis from July 2011 to December 2017 were enrolled.The patients were randomly divided into observation group(n=59)and control group(n=59).The control group was treated with Budesonide alone,the observation group was treated with Budesonide+Lidocaine.The therapeutic effects,symptom improvement,adverse reaction rate and inflammatory factors[interleukin-8(IL-8),γ-interferon(IFN-γ),C-reactive protein(CRP)],Tumor necrosis factor-α(TNF-α)]levels before and after treatment of two groups were observed and compared.Result:The total effective rate of the observation group was 96.61%higher than that of the control group(84.75%)(P<0.05).After 5 days of treatment,the improvement time and hospitalization days of the observation group were shorter than that of the control group(P<0.05).After 5 days of treatment,the levels of IL-8,IFN-γ,CRP and TNF-αwere lower than those of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Budesonide combined with Lidocaine is effective in the treatment of acute laryngitis in children.It can effectively shorten the time of clinical symptom improvement,reduce the level of inflammatory factors,having less adverse reactions and higher safety.