化痰降逆法联合奥美拉唑治疗咽喉反流病的临床研究

Clinical study of phlegm-resolving and adversity-reducing therapy combined with omeprazole in the treatment of laryngopharyngeal reflux disease

目的观察化痰降逆法联合奥美拉唑治疗咽喉反流病(Laryngopharyngeal Reflux,LPR)的疗效。方法选取2018年3月~2019年3月于辽宁中医药大学附属医院耳鼻喉科诊断为LPR且为痰气互结证的患者90例,随机分为对照组和治疗组各45例。对照组奥美拉唑肠溶片(20 mg)日二次口服,治疗组在对照组基础上联合使用自拟咽炎代茶颗粒100 ml日二次口服及四七气丸1丸日二次口服,疗程均为4周。分别于治疗前、治疗4周时各行一次电子喉镜检查,对比咽喉反流症状指数评分量表(reflux symptom index,RSI)和咽喉反流体征评分量表(reflux finding score,RFS),检测咽部Ryan指数,并进行疗效评价。结果两种治疗方式均能够改善咽喉反流症状,且治疗组方案优于对照组方案。结论化痰降逆法联合奥美拉唑治疗咽喉反流病的临床疗效显著,值得临床上推广应用。

Objective To observe the effect of resolving phlegm and reducing adverse reaction combined with omeprazole in the treatment of Laryngopharyngeal Reflux(LPR).Methods Ninety patients with LPR diagnosed by Otolaryngology Department of Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from March 2018 to March 2019 were randomly divided into control group and treatment group with 45 cases in each.The control group was given omeprazole enteric-coated tablets(20 mg)twice a day,while the treatment group was given Yanyan Daicha granules(100 ml)twice a day and Siqi Qi pills(1 pill)twice a day for 4 weeks.Electronic laryngoscopy was performed before treatment and 4 weeks after treatment.The reflux symptom index(RSI)and reflux finding score(RFS)were compared.The Ryan index of pharynx was measured and the curative effect was evaluated.Results Both treatment methods can improve the symptoms of laryngopharyngeal reflux,and the treatment group is better than the control group.Conclusions The method of resolving phlegm and reducing adverse reactions combined with omeprazole is effective in the treatment of laryngopharyngeal reflux disease,which is worthy of clinical application.