槐杞黄颗粒辅助治疗小儿过敏性紫癜30例临床观察

Clinical observation on Huaiqihang Keli (槐杞黄颗粒) as an adjunctive treatment for 30 cases of infantile Henoch-Schonlein purpura

目的观察槐杞黄颗粒辅助治疗小儿过敏性紫癜(HSP)的临床疗效。方法将60例HSP患儿随机分为治疗组和对照组,各30例。对照组口服维生素C片、芦丁片,治疗组在对照组治疗方法的基础上口服槐杞黄颗粒,连续治疗12周后统计疗效。结果对照组总有效率为73.33%,治疗组为93.33%,2组比较,差异有统计学意义(P<0.05)。治疗组紫癜与腹痛消失时间均短于对照组,差异有统计学意义(P<0.01);但2组关节痛消失时间比较,差异无统计学意义(P> 0. 05)。对照组复发8例(36.36%),治疗组复发2例(7.14%),2组比较,差异有统计学意义(P<0.05)。2组治疗前尿微量白蛋白(m Abl)、β2微球蛋白(β2-MG)水平比较,差异均无统计学意义(P>0.05),具有可比性。治疗后,2组上述指标均明显下降(P<0.05),且治疗组下降更显著(P<0.05)。结论槐杞黄颗粒辅助治疗小儿HSP疗效显著,复发率低。

Objective To observe the clinical efficacy on Huaiqihang Keli( 槐杞黄颗粒) as an adjunctive treatment for infantile Henoch-Schonlein purpura( HSP).Methods Sixty cases with HSP were randomly divided into treatment group and control group,with 30 cases in each.The control group was given oral vitamin C tablets and rutin tablets,while the treatment group was added with oral Huaiqihang Keli based on the treatment of the control group.We made statistics on clinical efficacy after 12 weeks consecutive treatment.Results The total effective rate of the control group was 73. 33%,that of the treatment group was 93. 33%,there was statistically significant difference between the two groups( P<0.05).The disappearance time of purpura and abdominalgia in the treatment group was both shorter than that in the control group,there was statistically significant difference between the two groups( P<0.01).But there was no significant difference in the disappearance time of arthrodynia between the two groups( P> 0.05). Eight cases( 36.36%) relapsed in the control group,while 2 cases( 7. 14%) relapsed in the treatment group,there was significant difference between the two groups( P < 0. 05). There were no significant differences in the levels of m Abl and β2-MG between the two groups before treatment( P>0.05),and they had comparability.After treatment,the above-mentioned indicators of the two groups both decreased significantly( P<0.05),moreover,those of the treatment group decreased more significantly( P<0.05).Conclusion Huaiqihang Keli as an adjunctive treatment for HSP has significant clinical efficacy with low relapse rate.