玉屏风散对过敏性紫癜患儿激素应用时间及免疫功能调节的影响

Effects of Yupingfeng San (玉屏风散) in hormone application time and immune regulation in children with Henoch-Schonlein purpura

目的探讨玉屏风散对过敏性紫癜(HSP)患儿激素应用时间及免疫功能调节的影响。方法选取2012年12月至2017年12月在海宁市中心医院治疗的HSP患儿60例,采用随机数字表法分为治疗组和对照组,各30例。对照组给予常规对症治疗,治疗组在对照组治疗方法的基础上给予玉屏风散治疗。2组均治疗4周后,观察和记录临床疗效、临床症状缓解时间、免疫功能、激素应用减少时间、不良反应发生情况。结果治疗组总有效率为93.33%,明显高于对照组的73.33%,2组比较,差异有统计学意义(P<0.05)。治疗组在紫癜、胃肠道症状、关节肿痛、皮疹缓解时间及激素应用减少时间方面均显著短于对照组,差异有统计学意义(P<0.05)。治疗前,2组IgA、IgE、IgG水平比较,差异均无统计学意义(P>0.05),具有可比性;与同组治疗前比较,治疗后2组IgA、IgE水平均明显降低(P<0.05),且治疗组降幅显著优于对照组(P<0.05); 2组治疗前后IgG水平比较,差异无统计学意义(P> 0.05)。治疗组和对照组的不良反应总发生率分别为13.33%,9.99%,2组比较,差异无统计学意义(P> 0.05)。结论玉屏风散辅助治疗HSP患儿,不仅可有效改善临床症状、免疫功能,而且还可减少激素应用时间和提高疗效,安全性良好,值得临床推广应用。

Objective To explore the effects of Yupingfeng San( 玉屏风散) in hormone application time and immune regulation in children with Henoch-Schonlein purpura( HSP). Methods Sixty children with HSP were chosen from December 2012 to December 2017 in Haining Central hospital,and they were divided into treatment group and control group according to the random number table method,30 cases in each one.The control group was given routine symptomatic treatment,while the treatment group was given Yupingfeng San therapy on the basis of the control group.After both groups were treated for 4 weeks,the clinical efficacy,remission time of clinical symptoms,immune function,hormone reduction time,the incidence of adverse reactions in the 2 groups were observed and recorded.Results The total effective rate of the treatment group was 93. 33%,which was significantly higher than73.33% of the control group,the difference was statistically significant between the two groups( P<0.05).The time of purpura,gastrointestinal tract symptoms,joint swelling and pain,rash,hormone application reduction time in the treatment group were significantly shorter than those in the control group,the differences were statistically significant( P<0.05).Before treatment,there was no significant difference in the levels of IgA,IgE and IgG between the 2groups( P>0.05),they were comparable. Compared with the same group before treatment,the levels of IgA and IgE in the 2 groups after treatment were significantly decreased( P<0.05),moreover,the decrease extent was more significant in the treatment group( P < 0. 05). There was no significant difference in the level of IgG between the 2groups before and after treatment( P > 0. 05). The adverse reactions rates in the treatment group and the control group were 13.33% and 9. 99% respectively,and the difference was not statistically significant between the two groups( P>0.05).Conclusion Yupingfeng San in adjuvant treatment of children with HSP can effectively improve the clinical symptoms and immune function,and it is beneficial to reduce the hormone application time and improve the therapeutic effect.With good security,it deserves clinical promotion and application.