中西医结合治疗小儿多动症痰热型56例临床观察

Clinical observation on 56 cases of pediatric attention deficit hyperactivity disorder with phlegm heat type treated by combined traditional Chinese and Western medicine

目的观察自拟镇心汤联合西药治疗小儿多动症痰热型的临床疗效。方法选取2015年1月至2017年10月于嵊州市妇幼保健院儿科接受治疗的多动症痰热型患儿112例,按照随机数字表法分为对照组和治疗组,各56例。对照组予利他林片口服治疗,治疗组在对照组治疗方法的基础上予自拟镇心汤口服治疗,均治疗8周后,比较2组的临床疗效、斯诺佩评估量表(SNAP-IV)、康纳尔父母量表(Conners)积分情况以及不良反应发生情况。结果治疗组总有效率为89.29%,明显高于对照组的69.64%,2组比较,差异有统计学意义(P<0.05)。治疗前,2组SNAP-IV、Conners量表积分比较,差异均无统计学意义(P>0.05),具有可比性。治疗后,在症状积分和多动指数方面,2组均较同组治疗前明显改善,差异均有统计学意义(P<0.05),且治疗组改善更显著(P<0.05)。对照组总不良反应发生率为7.14%,治疗组为3.57%,2组比较,差异无统计学意义(P>0.05)。结论自拟镇心汤联合西药治疗小儿多动症痰热型的临床疗效确切,且用药安全,值得临床推广应用。

Objective To observe the clinical efficacy of self-made Zhenxin Tang(镇心汤)combined with Western medicine in the treatment of pediatric attention deficit hyperactivity disorder(ADHD)with phlegm heat type.Method Totally 112 cases of ADHD with phlegm heat admitted to department of pediatrics of Shengzhou Maternal and Child Health Hospital from January 2015 to October 2017 were divided into control group and treatment group according to random number table method,with 56 cases in each.The control group was given oral ritalin tablets,while the treatment group was given self-made Zhenxin Tang orally on the basis of the control group.After both groups were treated for 8 weeks,the clinical efficacy,the scores of Swanson,Nolan and Pelham Questionnaire,Version IV(SNAP-IV)Rating scale-parent form and Conners Parent Symptom Questionaire(PSQ)and the incidence of adverse reactions were compared.Results The total effective rate of the treatment group was 89.29%,which was significantly higher than 69.64%of the control group,there was statistically significant difference between the two groups(P<0.05).Before treatment,the difference was not statistically significant in the scores between the SNAP-IV rating scale and Conners scale(P>0.05),and they were comparable.After treatment,the symptom scores and hyperactivity index of the two groups all improved significantly compared with the same group before treatment,and the difference were statistically significant(P<0.05),moreover,the treatment group improved more significantly(P<0.05).The total adverse reactions rate of the control group was 7.14%,that of the treatment group was 3.57%,but there was no statistically significant difference between the two groups(P>0.05).Conclusion Self-made Zhenxin Tang combined with Western medicine has a definite clinical efficacy on pediatric ADHD with phlegm heat type,and is safe to use,which is worthy of clinical promotion and application.