舒咳颗粒治疗小儿咳嗽变异性哮喘(发作期)40例临床观察

Clinical observation on 40 cases of children with cough variant asthma (attacking stage) treated by Shuke Keli (舒咳颗粒)

目的观察舒咳颗粒治疗小儿咳嗽变异性哮喘(发作期)的临床疗效。方法选取2015年6月至2017年5月在福建中医药大学附属宁德市中医院儿科门诊就诊的80例咳嗽变异性哮喘(发作期)患儿,随机分为治疗组和对照组,各40例。治疗组给予舒咳颗粒口服,对照组给予酮替芬和沙丁胺醇片口服。2组均7 d为1个疗程,连续治疗2个疗程后,统计2组的临床疗效、治疗前后日间和夜间咳嗽症状积分的变化情况。结果治疗组总有效率为92.5%,显著高于对照组的72.5%,2组比较,差异有统计学意义(P<0.05)。治疗前,2组日间和夜间咳嗽症状积分比较,差异均无统计学意义(P>0.05),具有可比性;治疗后,2组日间和夜间咳嗽症状积分均比同组治疗前下降(P<0.01),且治疗组积分下降程度优于对照组,差异均有统计学意义(P<0.01)。结论舒咳颗粒治疗小儿咳嗽变异性哮喘(发作期)临床疗效满意,可以显著改善患儿咳嗽症状。

Objective To observe the clinical efficacy of Shuke Keli(舒咳颗粒)in the treatment of children with cough variant asthma(attacking stage).Methods Eighty cases of children with cough variant asthma(attacking stage)consulted in out-patient service in department of pediatrics in Ningde TCM Hospital Affiliated to Fujian University of Chinese Medicine from June 2015 to May 2017 were chosen and randomly divided into treatment group and control group,with 40 cases in each.The treatment group was given Shuke Keli orally,while the control group was given oral administration of ketotifen and albuterol tablets.Seven days constituted 1 course of treatment for the 2 groups,after 2 consecutive courses of treatment,we kept statistics about the clinical efficacy and changes of diurnal and nocturnal cough symptom scores before and after treatment of the 2 groups.Results The total effective rate of the treatment group was 92.5%,which was significantly higher than 72.5%of the control group,and the difference was statistically significant between the two groups(P<0.05).Before treatment,the difference was not statistically significant in diurnal and nocturnal cough symptom scores between the two groups(P>0.05),and they were comparable.After treatment,diurnal and nocturnal cough symptom scores of the two groups all decreased significantly compared with the same group before treatment(P<0.01),moreover,the scores decrease extent of the treatment group was superior to that of the control group,and the difference was statistically significant(P<0.01).Conclusion It has satisfactory clinical efficacy to use Shuke Keli in the treatment of children with cough variant asthma(attacking stage),which markedly improves the cough symptoms of the children patients.