中西医结合治疗小儿肺炎支原体感染后慢性咳嗽40例临床观察

Clinical observation on 40 cases of chronic cough after mycoplasma pneumoniae infection in children treated by combined traditional Chinese and Western medicine

目的观察中西医结合治疗小儿肺炎支原体感染后慢性咳嗽的临床疗效。方法选取2016年1月至2017年12月湖州市南浔区中医院儿科收治的小儿肺炎支原体感染后慢性咳嗽患儿80例,按照随机数字表法分为治疗组和对照组,各40例。对照组予孟鲁司特钠咀嚼片联合阿奇霉素干混悬剂口服,治疗组在对照组治疗方法的基础上加用小儿消积止咳口服液,连续治疗14 d后,统计2组的临床疗效和安全性。结果治疗前,2组血沉(ESR)、C-反应蛋白(CRP)水平比较,差异无统计学意义(P>0.05),具有可比性;治疗后,2组ESR、CRP水平较同组治疗前显著降低,且治疗组降低更显著,差异均有统计学意义(P<0.05)。治疗前,2组主、次症积分比较,差异无统计学意义(P>0.05),具有可比性;治疗后,2组主、次症积分均较同组治疗前显著下降,且治疗组下降更显著,差异均有统计学意义(P<0.05)。对照组总有效率为80.0%,治疗组为97.5%,2组比较,差异有统计学意义(P<0.05)。对照组总不良反应发生率为20.0%,治疗组为2.5%,2组比较,差异有统计学意义(P<0.05)。结论中西医结合治疗小儿肺炎支原体感染后慢性咳嗽疗效显著,且安全性高,值得临床推广应用。

Objective To observe the clinical efficacy of combined traditional Chinese and Western medicine in the treatment of chronic cough after mycoplasma pneumoniae infection in children.Methods Eighty children with chronic cough after mycoplasma pneumoniae infection were admitted to department of pediatrics in Huzhou Municipal Nanxun District Hospital of TCM from January 2016 to December 2017 were divided into treatment group and control group according to random number table method,with 40 cases in each.The control group was given montelukast sodium chewable tablets combined with azithromycin for suspension orally.On this basis,the treatment group was added with Xiao’er Xiaoji Zhike Koufuye(小儿消积止咳口服液),the statistics were kept about the clinical efficacy and safety of the 2 groups after consecutive treatment for 14 days.Results Before treatment,the difference was not statistically significant in the levels of erythrocyte sedimentation rate(ESR)and C-reactive protein(CRP)between the two groups(P>0.05),and they were comparable.After treatment,the levels of ESR and CRP of the two groups all significantly decreased compared with the same group before treatment,moreover,the treatment group decreased more significantly,and the difference was statistically significant(P<0.05).Before treatment,the difference was not statistically significant in cardinal and minor symptoms scores between the two groups(P>0.05),and they were comparable.After treatment,the cardinal and minor symptoms scores of the two groups all significantly decreased compared with same group before treatment,moreover,the treatment group decreased more significantly,and the difference was statistically significant(P<0.05).The total effective rate of the control group was 80.0%,that of the treatment group was 97.5%,and the difference was statistically significant between the two groups(P<0.05).The total adverse reactions rate of the control group was 20.0%,that of the treatment group was 2.5%,and the difference was statistically significant between the two groups(P<0.05).Conclusion It has significant curative effects and high security to use combined traditional Chinese and Western medicine in the treatment of chronic cough after mycoplasma pneumoniae infection in children,which deserves clinical promotion and application.