苇茎汤加味联合红霉素治疗小儿百日咳综合征痉咳期46例临床观察

Clinical observation on 46 cases of pediatric pertussis syndrome with stage of spasmodic cough treated by modified Weijing Tang (苇茎汤)combined with erythromycin

目的观察苇茎汤加味联合红霉素治疗小儿百日咳综合征痉咳期的临床疗效。方法选取2012年1月至2017年12月江阴市中医院儿科诊治的百日咳综合征痉咳期患儿92例,按随机数字表法分为对照组和治疗组,各46例。对照组予红霉素静脉滴注治疗,治疗组在对照组治疗方法的基础上口服苇茎汤加味,2组均7 d为1个疗程,连续治疗2个疗程后统计疗效。结果治疗组总有效率为97.83%,明显优于对照组的82.61%,2组比较,差异有统计学意义(P<0.05);治疗组痉咳缓解时间、痉咳天数、肺部啰音消失时间、治疗时间均明显短于对照组,2组比较,差异均有统计学意义(P<0.05)。结论苇茎汤加味联合红霉素治疗小儿百日咳综合征痉咳期可有效缓解临床症状,缩短疗程,疗效显著,值得临床推广应用。

Objective To observe the clinical efficacy of modified Weijing Tang(苇茎汤)combined with erythromycin in the treatment of pediatric pertussis syndrome with stage of spasmodic cough.Methods Ninety-two cases of pediatric pertussis syndrome with stage of spasmodic cough diagnosed and treated in pediatrics department of Jiangyin Hospital of TCM were divided into control group and treatment group according to random number table method,with 46 cases in each.The control group was given erythromycin intravenous drip,on this basis,the treatment group was given modified Weijing Tang orally.Seven days constituted 1 course of treatment for both groups,and we kept statistics about the curative effects after consecutive treatment for 2 courses of treatment.Results The total effective rate of the treatment group was 97.83%,which was significantly superior to 82.61%of the control group,and the difference between the two groups was statistically significant(P<0.05).The remission time of spasmodic cough,the days of spasmodic cough,the disappearance time of pulmonary rales and the treatment time in the treatment group were significantly shorter than those in the control group,and the difference between the two groups was statistically significant(P<0.01).Conclusion It can effectively alleviate the clinical symptoms,shorten the course of treatment with marked curatiue effects to use modified Weijing Tang combined with erythromycin in the treatment of pediatric pertussis syndrome with stage of spasmodic cough,which deserves clinical promotion and application.