基于昼夜节律研究针灸治疗类风湿关节炎的概况

Overview of Acupuncture Treating RA Research Based on Circadian Rhythm

类风湿关节炎(Rheumatoid Arthritis,RA)的临床症状具有关节肿胀、僵硬、疼痛晨起加重,白天缓解到相对稳定状态的典型的昼夜节律特征。前期研究发现其临床表现的昼夜节律变化归因于RA细胞因子和激素水平的昼夜振荡,而基于RA昼夜节律性制定的药物时间疗法已经取得了突破性的临床进展。而针对RA的昼夜节律性,针灸治疗也取得了相应的研究进展;对RA病理生理的昼夜节律性以及针灸如何基于其昼夜振荡对RA进行良性调节进行检索、整理、总结,并进行综述。

The clinical syndromes of rheumatoidarthritis is characterized as the classic circadian rhythm,such as the stiffness and pain of joints are more serious at the early morning and relief in the afternoon.Several studies have verified that the diurnal oscillation of RA is attributed to the circadian variation of pro-inflammatory cytokines and hormones related to RA.In according to these results,the chronobiology and pharmacology improved the dosage form and time of taking medicine,and have made important progress.Based on circadian rhythm of RA,the research of acupuncture treating RA also have made some progress,so we summarized and recorded.