丹参舒心胶囊联合地尔硫卓治疗血瘀型难治型心绞痛的临床研究

Clinical Study of Danshen Shuxin Capsule Combined with Diltiazem in Treatment of Refractory Angina Pectoris with Blood Stasis Type

目的:探讨对血瘀型难治型心绞痛患者应用丹参舒心胶囊与地尔硫卓联合治疗后对其临床疗效的影响情况。方法:选取98例血瘀型难治型心绞痛患者作为临床研究对象,入院时间为2016年12月—2018年3月期间,采用随机数字表法分为对照组(地尔硫卓治疗,49例)和观察组(丹参舒心胶囊与地尔硫卓联合治疗,49例)。对比治疗后患者的心功能以及各临床症状改善情况。结果:经治疗后,观察组血浆黏度(1.44±0.100)、红细胞压积(39.09±3.26)%、低切(10.19±1.02)CP以及高切(3.57±0.41)CP水平明显低于对照组的血浆黏度(1.51±0.129)、红细胞压积(44.42±3.87)%、低切(11.40±1.09)CP以及高切(3.72±0.30)CP;观察组LVESD(0.95±0.10)mm、LVEDD(46.24±8.11)mm以及LVEF(54.33±9.99)%水平明显高于对照组的LVESD(1.18±0.12)mm、LVEDD(52.04±9.32)mm以及LVEF(48.76±9.47)%;观察组心绞痛发作次数(2.48±1.98)次/周以及心绞痛持续时间(2.01±1.18)min明显低于对照组的心绞痛发作次数(5.12±2.31)次/周以及心绞痛持续时间(5.01±1.88)min,差异均具有统计学意义(P<0.05)。结论:对于血瘀型难治型心绞痛患者,采用丹参舒心胶囊与地尔硫卓联合治疗可有效改善患者心功能水平,降低心绞痛发作频率及时间。

Objective:To investigate the clinical effect of Danshen Shuxin Capsule combined with diltiazem on patients with refractory angina pectoris of blood stasis type.Methods:Ninety-eight patients with blood stasis type of refractory angina pectoris were selected as clinical subjects.According to the time of admission from December 2016 to March 2018,the patients were divided into control group(diltiazem treatment,49 cases)and observation group(combination of Danshen Shuxin Capsule and diltiazem,49 cases).The cardiac function and the improvement of clinical symptoms were compared after treatment.Results:After treatment,the plasma viscosity(1.44±0.100),hematocrit(39.09±3.26)%,whole blood viscosity low cut(10.19±1.02)CP and whole blood viscosity high cut(3.57±0.41)CP in the observation group were significantly lower than those of the control group(plasma viscosity(1.51±0.129),hematocrit(44.42±3.87)%,whole blood viscosity low cut(11.40±39.09)CP and whole blood viscosity high cut(3.72±0.30)CP)The levels of LVESD(0.95±0.10)mm,LVEDD(46.24±8.11)mm and LVEF(54.33±9.99)%in the observation group were significantly higher than those of the control group(LVESD(1.18±0.12)mm,LVEDD(52.04±9.32)mm and LVEF(48.76±9.47)%)The duration of angina pectoris(2.01±1.18)min was significantly lower than that of the control group(5.12±2.31)/week and the duration of angina pectoris(5.01±1.88)min.and the difference was statistically significant(P<0.05).Conclusion:The combination of Danshen Shuxin Capsule and diltiazem can effectively improve the cardiac function and reduce the frequency and time of angina pectoris in patients with refractory angina pectoris.