蒲地蓝口服液联合更昔洛韦对痰热炽盛型传染性单核细胞增多症患儿心肌损伤及免疫功能的影响

Effect of Combination of Pudilan Oral Liquid and Ganciclovir on Myocardial Injury and Immune Function in Children with Infectious Mononucleosis with Phlegm Heat Syndrome

目的:观察蒲地蓝口服液联合更昔洛韦治疗痰热炽盛型传染性单核细胞增多症的临床疗效,并观察其对心肌损伤及免疫功能的影响。方法:随机选取80例痰热炽盛型传染性单核细胞增多症(infectious mononucleosis,IM)患儿,随机分为两组,对照组患者给予更昔洛韦治疗,研究组给予蒲地蓝口服液联合更昔洛韦治疗。比较两组更外周血异型淋巴细胞比例、外周血白细胞计数、外周血淋巴细胞比例、心肌酶指标、T淋巴细胞及NK细胞的水平;比较两组的临床症状及体征积分、临床疗效及不良反应发生情况。结果:治疗后研究组的异型淋巴细胞比例、白细胞计数明显降低(P<0.05),淋巴细胞比例明显升高(P<0.05),并且显著较对照组变化幅度大(P<0.05);研究组治疗后CK-MB、cTnT及LDH明显低于治疗前(P<0.05),并且各指标均显著低于对照组(P<0.05);治疗后两组的临床症状及体征积分均有不同程度的降低(P<0.05),而研究组较对照组降低的更为显著(P<0.05);研究组总有效率92.5%,对照组总有效率72.5%,研究组患儿临床总有效率显著高于对照组(P<0.05);研究组的不良反应率显著少于对照组(P<0.05)。结论:蒲地蓝口服液联合更昔洛韦治疗痰热炽盛型传染性单核细胞增多症抗疗效确切,临床症状改善明显,值得临床推广。

Objective:To observe the clinical efficacy of Pudilan Oral Liquid and ganciclovir in the treatment of infectious mononucleosis with phlegm heat sydnrome and observe its effect on myocardial injury and immune function.Methods:Eighty cases of infectious mononucleosis(IM)were randomly selected and randomly divided into two groups.The control group was treated with ganciclovir,and the study group was treated with Pudilan Oral Liquid combined with ganciclovir.The ratio of peripheral blood heterocyst,peripheral blood white blood cell count,peripheral blood lymphocyte proportion,myocardial enzyme index,T lymphocyte and NK cell level were compared between the two groups,and the clinical symptoms and signs,clinical effects and adverse reactions in the two groups were compared.Results:After treatment,the proportion of heterocyst and white blood cell count decreased significantly(P<0.05),the proportion of lymphocyte increased significantly(P<0.05),and significantly higher than that of the control group(P<0.05).After treatment,the CK-MB,cTnT and LDH were significantly lower than those before treatment(P<0.05),and the indexes were all obvious.Compared with the control group(P<0.05),the clinical symptoms and signs scores of the two groups were reduced in varying degrees(P<0.05),but the study group’s was more significantly lower than that of the control group(P<0.05).The total effective rate of the study group was 92.5%and the total effective rate of the control group was 72.5%.The total clinical effective rate of the children in the study group was significantly higher than that of the control group(P<0.05).The adverse reaction rate of the study group was significantly less than that of the control group(P<0.05).Conclusion:The treatment of infectious mononucleosis with phlegm heat sydnrome with ganciclovir and Pudilan Oral Liquid is effectiveand the clinical symptoms are improved obviously.It is worthy of clinical promotion.