复方苦参注射液联合化疗治疗非小细胞肺癌骨转移疼痛的疗效

Effect of Compound Kushen Injection Combined with Chemotherapy in Treating Bone Metastasis Pain of Non-Small Cell Lung Cancer

目的:探讨复方苦参注射液联合化疗治疗非小细胞肺癌骨转移疼痛的疗效。方法:选择非小细胞肺癌伴发骨转移患者98例,按照随机数字的方法分为两组,对照组和观察组,每组49例患者,对照组采用TP化疗方案,观察组在对照组治疗方法基础上给予复方苦参注射液,对两组的近期治疗效果,生活质量,疼痛程度和不良反应情况进行比较。结果:观察组的治疗效果、治疗有效率和疾病控制率均优于对照组,数据差异具有统计学意义(z=-4.591,χ~2=4.350,9.524,P<0.05),观察组生活质量改善程度优于对照组,数据差异具有统计学意义(z=-2.606,P<0.05),经过治疗后,对照组的VAS评分从(7.21±2.03)分降低到(5.36±1.53)分,观察组的VAS评分从(7.31±2.11)分降低到(3.57±1.47)分,观察组的降低幅度大于对照组,数据差异具有统计学意义(t=5.906,P<0.05),观察组出现腹泻,表细胞减少,血小板降低的比例低于对照组,数据差异具有统计学意义(χ~2=4.804,12.119,4.504,P<0.05),两组恶性呕吐,脱发的发生率数据差异不具有统计学意义(χ~2=0.041,0.049,P>0.05)。结论:使用复方苦参注射液联合化疗治疗非小细胞肺癌骨转移的患者,可以缓解疼痛,提高治疗效果和生活质量。

Objective:To explore the effect of Compound Kushen Injection combined with chemotherapy on bone metastasis pain in non-small cell lung cancer.Methods:98 patients with non-small cell lung cancer with bone metastasis were selected.According to the random number method,the patients were divided into the control group and the observation group,with 49 patients in each group.The control group was treated with TP chemotherapy,while the observation group was treated with Compound Kushen Injection on the basis of the control group.The short-term therapeutic effects,quality of life,pain and adverse reactions of the two groups were compared.Result:The therapeutic effect,treatment efficiency and disease control rate of the observation group were better than those of the control group,and the data was statistically significant(z=-4.591,χ2=4.350,9.524,P<0.05).The improvement of quality of life in the observation group was better than that in the control group,and the data was statistically significant(z=-2.606,P<0.05).After treatment,the VAS score of the control group decreased from(7.21±2.03)points to(5.36±1.53)points,and the VAS score of the observation group decreased from(7.31±2.11)points to(3.57±1.47)points.The reduction of patients in the observation group was greater than that in the control group,and the data was statistically significant(t=5.906,P<0.05).Patients in the observation group developed diarrhea,decreased surface cells and the proportion of platelet reduction was lower than that of the control group.The difference was statistically significant(χ~2=4.804,12.119,4.504,P<0.05).There was no statistically significant difference in the incidence of malignant vomiting and alopecia between the two groups(χ~2=0.041,0.049,P>0.05).Conclusion:Non-small cell lung cancer patients with bone metastases treated with Compound Kushen Injection combined with chemotherapy can relieve pain and improve treatment effect and quality of life.