苍柴调中汤联合沙格列汀对胰岛素抵抗合并肥胖治疗效果观察

Analysis of Effect in Patients with Insulin Resistance and Obesity by Cangchai Tiaozhao DecoctionCombined with Saxagliptin

目的:探究胰岛素抵抗合并肥胖经苍柴调中汤结合沙格列汀治疗的效果及其糖代谢的影响。方法:选取60例胰岛素抵抗并肥胖的门诊病人,按照随机数表法分为观察组和对照组,每组30例,对照组使用沙格列汀进行治疗,观察组采用苍柴调中汤结合沙格列汀进行治疗,观察比较两组患者的临床疗效、治疗前、后糖代谢指标空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1C)的变化情况以及腰围、体质量指数(BMI)指标的变化情况。结果:观察组患者总有效率(96.67%)明显高于对照组(80.00%),两组比较有统计学意义(P<0.05),治疗前,两组患者的FPG、2 h PG、HbA1C指标比较均无差异(P>0.05),治疗后,观察组患者FPG(5.39±1.59)mmol/L、2 h PG(8.37±1.51)mmol/L、HbA1C[(6.37±1.61)%]均明显低于对照组[(6.83±1.72)mmol/L、(9.41±1.56)mmol/L、[(7.38±1.93)%]],两组比较有统计学意义(P<0.05),治疗前,两组患者的腰围以及BMI指标比较无差异(P>0.05),治疗后,观察组腰围(100.13±7.08)cm以及BMI(27.83±1.02)kg/m2明显低于对照组[(103.97±7.56)cm、(29.64±1.25)kg/m2],两组比较有统计学意义(P<0.05)。结论:苍柴调中汤结合沙格列汀对治疗胰岛素抵抗并肥胖疗效显著,能够有效降低患者的糖代谢水平,改善患者胰岛素抵抗以及肥胖,值得临床推广应用。

Objective:To study the effect in patients with insulin resistance and obesity by Cangchai Tiaozhao Decoction combined with Saxagliptin.Methods:Sixty cases of patients were divided into the observation group(30 cases)and the control group(30 cases).The control group was given Saxagliptin while the observation group received Cangchai Tiaozhao Decoction combined with Saxagliptin.The treatment effect,FPG,2 h PG,HbA1 C,waist circumference and BMI of two groups were compared.Results:Total efficiency(96.67%)of the observation group was significantly higher than the control group’s(80.00%).The difference was statistically significant(P<0.05).FPG,2 h PG and HbA1 C of two groups were not statistically significant(P>0.05)before treatment.FPG(5.39±1.59)mmol/L,2 hPG(8.37±1.51)mmol/L and HbA1 C(6.37±1.61)%of the observation group were significantly lower than the control group’s(6.83±1.72)mmol/L,(9.41±1.56 mmol/L)and(7.38±1.93)%after treatment.The difference was statistically significant(P<0.05).Waist circumference and BMI of two groups were not statistically significant(P>0.05)before treatment.Waist circumference(100.13±7.08)cm and BMI(27.83±1.02)kg/m^2 of the observation group were significantly lower than the control group’s(103.97±7.56)cm and(29.64±1.25)kg/m2 after treatment.The difference was statistically significant(P<0.05).Conclusion:Cangchai Tiaozhao Decoction combined with Saxagliptin had a treatment effect obviously in patients with insulin resistance and obesity.It could effectively reduce the level of glucose metabolism and improve the insulin resistance and obesity.It was worthy of clinical application.