江苏地区无症状颈动脉粥样硬化自然病程演变与中医体质相关性的5年随访研究

A Five-year Follow-up Study of Correlation between The Natural Evolution of Carotid Atherosclerosis in Asymptomatic Individuals of Jiangsu Province and Their TCM Constitutions

目的:研究江苏地区无症状颈动脉粥样硬化患者病程演变与中医体质分布和病程演变与中医体质的相关性?方法:调查297例无症状颈动脉粥样硬化患者初访及5年后的临床及体质资料?分析其体质分布特点?并行动脉粥样硬化演变与中医体质相关多元Logistic回归分析?结果:无症状颈动脉粥样硬化者在5年随访前后体质分布构成无明显改变?动脉粥样硬化进展与男女性别无明显相关?以体质因素对CIMT和斑块积分行多元Logistic回归分析?进入方程的与CIMT进展相关体质是阳虚质、痰湿质与湿热质?而与斑块积分进展相关的中医体质是阳虚质、痰湿质和瘀血质?结论:无症状颈动脉粥样硬化者中医体质有相对的稳定性?阳虚质、痰湿质与湿热质为无症状颈动脉粥样硬化者CIMT进展的危险体质因素?阳虚质、痰湿质和瘀血质是斑块积分进展的体质危险因素?

Objective:To investigate the distribution of TCM constitutions of asymptomatic carotid atherosclerosis(ACAS)patients living in Jiangsu province and evaluate the correlationship between spontaneous evolution of carotid atherosclerosis and their TCM constitutions.Methods:297 ACAS cases were included in this 60 months follow-up study,with TCM constitutions,clinical and ultrasonography exams carried.Multiple Logistic regression analysis was used to measures the correlationship between the atherosclerosis progression and TCM constitutions.Results:No significant differences of TCM constitution distribution were observed between the first and the last follow-up.No difference of the atherosclerosis progression was found between the male and female patients.According to the Multiple Logistic analysis,yang-deficiency constitution,phlegm-damp constitution and damp-heat constitution were factors taken into the equation which is related to the progression of CIMT,while the yang-deficiency constitution,phlegm-damp constitution and blood-stasis constitution is related to the plaque score.Conclusion:The TCM constitutions of asymptomatic atherosclerosis individuals have their stabilities in the atherosclerosis progression.Yang-deficiency constitution,phlegm-damp constitution and damp-heat constitution are risk factors of the progression of CIMT,and the yang-deficiency constitution,phlegm-damp constitution and blood-stasis constitution are the risk factors of the plaque score progression of asymptomatic atherosclerosis individuals.