克拉玛依地区糖尿病前期人群BMI和血脂水平相关性研究

The Correlation study on BMI and serum lipid level in prediabetic people in Karamay area

目的探讨克拉玛依地区糖尿病前期人群BMI和血脂水平的关系,并为克拉玛依地区糖尿病前期防治提供依据。方法采用病例对照研究方法,选取2016年3月—2017年10月在克拉玛依市中心医院健康管理中心进行健康检查的检查者1 020名,其中糖尿病前期组(观察组)216名,糖耐量正常组(正常对照组)804名,由研究人员对健康检查者进行体格检查和生化指标等检查。结果观察组体重(BW)、体质指数(BMI)、总胆固醇(TC)、甘油三酯(TG)、收缩压、舒张压和低密度脂蛋白胆固醇(LDL-C)均高于正常对照组,高密度脂蛋白胆固醇(HDL-C)显著低于正常对照组,且差异均有统计学意义(均P<0.01);观察组的超重及肥胖检出率为68.8%、高甘油三酯血症检出率为39.3%、高胆固醇血症检出率为37.9%、混合型高脂血症检出率为14.8%、低高密度脂蛋白胆固醇血症检出率为41.6%和高低密度脂蛋白胆固醇血症检出率为23.1%均高于正常对照组的32.7%、13.0%、6.7%、2.4%、10.5%和12.5%,差异均有统计学意义(均P<0.01);经多因素非条件logistic回归分析结果显示:超重、肥胖、年龄>41岁、TC、TG、HDL-C和收缩压升高等均为克拉玛依区糖尿病前期人群发病的危险因素,OR值(95%CI)分别为2.9(1.87～4.50)、7.49(3.99～14.08)、0.41(0.19～0.89)、3.03(2.34～3.92)、1.20(1.01～1.43)、0.03(0.01～0.07)和1.02(1.00～1.04)。结论克拉玛依地区糖尿病前期的发生与该人群BMI和血脂水平具有关联性;健康膳食、适量运动和合理控制体重是预防克拉玛依地区糖尿病前期的发生和降低糖尿病前期转化为糖尿病的重要措施。

[Objective]To investigate the relationship between BMI and blood lipid level of prediabetic population in karamay area, and to provide evidence for the prevention and treatment of prediabetic population. [Methods] Case-control study method was adopted to select 1 020 inspectors in Health Management Center of Karamay Central Hospital from March 2016-October2017, including prediabetic group of 216 cases(observation group), normal glucose tolerance group of 804 cases(normal control group). The researcher carries on the physical examination and the biochemical index examinations to the health examination person.[Results]Body weight(BW), body mass index(BMI), total cholesterol(TC), triglyceride(TG), systolic blood pressure,diastolic blood pressure and LDL cholesterol(LDL-C) in the observation group were all higher than those in the normal control group, while HDL cholesterol(HDL-c) in the observation group was significantly lower than that in the normal control group(P<0.01). The detection rate of overweight and obesity(68.8%), hypertriglyceridemia(39.3%), hypercholesteremia(37.9%), mixed hyperlipidemia(14.8%), and low HDL cholesterol(41.6%), LDL cholesterol(23.1%) in observation group were higher than those of the normal control group(32.7%, 13.0%, 6.7%, 2.4%, 10.5% and 12.5%), with significant differences(P<0.01). The results of multivariate unconditioned logistic regression analysis showed that: overweight, obesity, age>41 years, TC, TG, HDL-C and elevated systolic blood pressure were risk factors for prediabetic population in Karamay District. OR values(95%CI) were 2.9(1.87-4.50), 7.49(3.99-14.08), 0.41(0.19-0.89), 3.03(2.34-3.92), 1.20(1.01-1.43), 0.03(0.01-0.07) and 1.02(1.00-1.04),respectively.[Conclusion]The prediabetes in karamay area is correlated with BMI and blood lipid level of prediabetic people.Healthy diet, moderate exercise and reasonable weight control are important measures to prevent the occurrence of prediabetes in Karamay area and reduce the conversion of prediabetes into diabetes.