苏子降气汤治疗慢性阻塞性肺疾病急性加重期的荟萃分析

Systematic Analysis of Suzi Jiangqi Decoction in Treating Acute Exacerbation of Chronic Obstructive Pulmonary Disease

目的运用系统评价方法评价苏子降气汤为主方的中药方剂治疗慢性阻塞性肺疾病急性加重期(AECOPD)的疗效。方法计算机检索Pub Med、中国知网(CNKI)、重庆维普全文数据库(VIP)、中国生物医学文献服务系统(CBM)和万方数据知识服务平台,搜索以苏子降气汤为主方治疗慢性阻塞性肺疾病急性加重期的完全随机对照试验,采用Rev Man 5.3软件进行Meta分析,用Jadad质量记分法进行偏倚风险评估,发表性偏倚采用倒漏斗图显示。结果共纳入12篇临床随机对照研究,共658例。Meta分析结果显示:与西药对照组相比,苏子降气汤在增强AECOPD患者氧分压和肺功能、改善二氧化碳储留有一定的效果。结论苏子降气汤为主方的中药方剂可以改善慢性阻塞性肺疾病急性加重期肺功能状态。

Objective To evaluate the efficacy of Suzi Jiangqi decoction in treating acute exacerbation of chronic obstructive pulmonary disease(COPD).Methods PubMed,(CNKI),Chongqing Weipu full-text database(VIP),Chinese biomedical literature service system(CBM)and Wanfang data knowledge service platform were examined by computer.A randomized controlled trial with Suzi Jiangqi decoction as the main prescription for treating acute exacerbation of chronic obstructive pulmonary disease(COPD)was conducted.Meta analysis was performed by RevMan 5.3 software,bias risk was assessed by Jadad quality scoring method,and inverted funnel was used as published bias.The picture shows.Results 12 clinical randomized controlled studies were conducted,including 658 cases.The results of Meta analysis showed that Suzi Jiangqi decoction could enhance the oxygen partial pressure and lung function in patients with AECOPD,and improve the storage of carbon dioxide.Conclusion Suzi Jiangqi decoction can improve pulmonary function in acute exacerbation of chronic obstructive pulmonary disease.