基于关联规则的慢性阻塞性肺疾病稳定期组方规律探讨

Analysis of the Composing Principle of Treating Stable COPD Based on Association Rules

目的探讨中医药治疗慢性阻塞性肺疾病(COPD)稳定期的常用药物组方规律。方法以1991年1月至2013年12月在省级以上期刊发表,以中医药为主用于COPD稳定期的治疗,且经过临床疗效观察有效的中药复方为研究对象,对其用药进行关联规则分析,探索中医药治疗COPD稳定期的常用药物组方规律。结果关联规则显示,COPD稳定期组方中,置信度高的药对为黄芪、防风;三药组合为黄芪、防风、白术;四药组合为白术、陈皮、甘草、党参;五药组合为白术、陈皮、甘草、党参、茯苓;六药组合为白术、半夏、陈皮、甘草、茯苓、黄芪。结论 COPD稳定期的用药是以扶正祛邪为主,扶正以补益肺脾气虚为主,祛邪以清肺化痰、活血化瘀为主。

Objective: To discuss the commonly used drug prescription rule of TCM in the treatment of stable COPD. Methods: TCM compound,with clinical effects in the main treatment of stable COPD,published in January 1991 to December 2103 on the journal,was taken into study,to analyze its association rules on the drug and explore the commonly used drug prescription rule of TCM in treatment of stable COPD. Results: The couplet medicines with higher reliability in the composing principle of treating stable COPD based on association rules was Astragalus and windbreak;three drug combination was Astragalus,Fangfeng and Atractylodes macrocephala;four drug combination was the white atractylodes rhizome,tangerine peel,liquorice and Radix Codonopsis;five drug combination was the white atractylodes rhizome,tangerine peel,liquorice,Radix Codonopsis and Poria cocos;six drug combination was the white atractylodes rhizome,Rhizoma Pinelliae,tangerine peel,liquorice,Poria and Radix astragali. Conclusion: The medication is mainly to strengthen the body resistance and to eliminate pathogenic factors in treating stable COPD. Strengthening the body resistance is mainly to tonify the lung and spleen deficiency;eliminating pathogenic is mainly to clear lung,eliminate phlegm,and promote blood circulation.