脉络宁注射液对缺血性中风血管内皮细胞损伤修复效果的观察

The Effect of Mailuoning Injection on the Injury Repair of Vascular Endothelial Cell in the Treatment of Ischemic Stroke

目的观察脉络宁注射液治疗缺血性中风对于血管内皮细胞损伤修复的效果。方法将144例患者根据随机抽签原则分为治疗组与对照组各72例,对照组给予西医基础治疗,在此基础上将脉络宁注射治疗添加用到治疗组患者中,两组疗程均为14 d。结果对照组和治疗组总有效率分别为84.72%和97.22%,治疗组明显较高(P<0.05)。通过治疗,两组的美国国立卫生研究院(NIHSS)评分都比治疗前要低(P<0.05),并且对照组明显要比治疗组高(P<0.05)。治疗组与对照组治疗后内皮细胞依赖性舒张功能均改善,治疗组改善程度优于对照组(P<0.05)。两组治疗后的血清血浆内皮素(ET)与血栓素B2(TXB2)表达值都呈现明显降低的趋势(P<0.05),治疗组的数值更低(P<0.05)。结论在治疗缺血性中风时使用脉络宁注射液可以加速修复血管的内皮细胞,使该细胞有着更好的舒张性,从而有效改善脑神经功能缺损状态,提高整体治疗的效果。

Objective: To discuss the effects of mailuoning injection on injury repair of vascular endothelial cell in the treatment of ischemic stroke. Methods: From February 2012 to January 2015,144 hospitalized patients with ischemic stroke were selected,according to the principle of random draw and were equally divided into the treatment group and the control group. The control group were given western medicine,on this basis,the treatment group with the Mailuoning injection therapy. Both groups were treated for 14 days. Results: After treatment,the efficient rates of the treatment group and the control group were 97.22% and 84.72% respectively,with significant difference in the treatment group(P < 0.05). After treatment,the NIHSS scores were significantly lower than before treatment in the two groups(P < 0.05),and the NIHSS scores in the treatment group after treatment were significantly lower than that of the control group(P < 0.05). The endothelium-dependent vasodilation in both groups was improved,the treatment group significantly higher the control group(P < 0.05). After treatment,the serum ET and TXB2 expression values showed significant decrease(P < 0.05),the treatment group significantly lower than the control group(P < 0.05). Conclusion: Mailuoning injection in the treatment of ischemic stroke can promote injury repair of vascular endothelial cell and improve endothelium-dependent vasodilation. Thus it can effectively improve the state of brain impairment and the overall effectiveness of treatment.