补中益气汤预防下肢骨折患者围手术期深静脉血栓形成的临床研究

A Clinical Study on the Prevention of Deep Venous Thrombosis of Patients with Lower Extremity Fractures during Perioperative Period with Buzhong Yiqi Decoction

目的观察补中益气汤预防下肢骨折患者围手术期深静脉血栓(DVT)形成的临床疗效性和安全性。方法 60例患者按照随机数字表法分为两组各30例。实验组常规抗炎、止痛治疗外加用中药补中益气汤。对照组常规抗炎、止痛治疗,不使用任何抗凝剂;观察所有病例用药后发生下肢DVT、血液流变学指标及血小板计数情况。结果术后3个月实验组出现下肢DVT 2例,明显少于对照组的11例(P<0.01);术后14 d两组患者血液流变学指标均较治疗前改善(P<0.05),实验组改善明显(P<0.01),血小板计数均较治疗前改善(P<0.01),治疗后组间差异无统计学意义(P>0.05)。结论围手术期预防性使用补中益气汤对预防下肢创伤骨折后DVT形成有效并且安全。

Objective: To investigate the clinical efficacy and safety of Buzhong yiqi decoction on deep vein thrombosis in the patients with lower limb fractures in the perioperative period. Methods: 60 patients were divided into the experimental and the control groups with random method. The experimental group took conventional anti-inflammatory,analgesic therapy,and medicine Buzhong yiqi decoction. The control group received anti-inflammatory and analgesic therapy. All patients with deep vein thrombosis,blood rheology and platelet count situation were observed. Results: After 3 months,the occuring rates of both groups had statistical significance(P <0.01). After 14 d,blood rheology of both groups were improved with statistical significance(P < 0.01),and the treatment group were more obvious. Compared with pre-treatment,the platelet count of both groups were improved with statistical significance(P < 0.01). There was no statistical significance between the two groups after treatment(P > 0.05). Conclusion: Buzhong yiqi decoction is effective in preventing the formation of deep vein thrombosis(DVT) and safe in the perioperative period.