仙元方凝胶剂灌肠和激素治疗儿童腹型过敏性紫癜临床观察

Curative Effect Analysis of Xianyuan Decoction Gelata Enema and Hormonal Treatment on Children with Abdominal Type Allergic Purpura

目的观察比较仙元方凝胶剂灌肠和激素在治疗儿童腹型过敏性紫癜的临床疗效。方法回顾性分析122例患儿病历资料,从临床表现和实验检查情况,比较分析腹型过敏性紫癜患儿中药灌肠治疗组及激素治疗组的临床疗效。结果两种方法治疗腹型儿童过敏性紫癜腹痛症状效果差别不大(P>0.05)。两组患者中的轻度疼痛均完全缓解,两组间差异无统计学意义(P>0.05);中度疼痛的完全缓解率分别为82.6%、88.24%,两组间差异无统计学意义(P>0.05);重度疼痛的完全缓解率分别为12.5%、64.29%。对于两组患者的来说,轻中度疼痛的有效率均为100%;重度疼痛的有效率分别为37.50%、85.71%,中药灌肠治疗优于激素治疗组(P<0.05)。患者实验室检查粪便潜血阳性的治疗效果中药灌肠组治疗总有效率为86.21%,好于激素治疗组的40.00%(P<0.05)。两种治疗方法对腹痛缓解时间比较差别不大,两组治疗对于缓解腹痛的起效时间相当(P>0.05)。结论中药仙元方凝胶剂灌肠和激素静滴对于腹型过敏性紫癜患儿腹痛的治疗均有良好疗效,而对于重度腹痛,激素治疗效果明显好于中药灌肠。对于实验室检查大便潜血阳性的患者中药灌肠的治疗效果明显好于激素治疗。

Objective: to observe and compare the curative effects of Xianyuan Decoction gelata enema and hormonal treatment on children with abdominal type allergic purpura. Methods: Retrospective analysis was made for the medical records of 122 cases of children. From the clinical manifestation and laboratory examination,the curative effects of Xianyuan Decoction gelata enema and hormonal treatment on children with abdominal type aller-gic purpura were compared and analyzed in the two group: TCM enema group and the hormonal treatment group.Results: There was no significant difference between the two groups in treating children with abdominal type allergic purpura(P > 0.05). Mild pain of both groups was completely relieved,with no statistical difference(P >0.05). The complete remission rate of moderate pain was 82.6% and 88.24%,respectively,with no statistical difference between the two groups(P > 0.05). The complete remission rate of severe pain was 12.5% and 64.29%,respectively. For the two groups,the effective rate of mild to moderate pain was 100%;the effective rates of severe pain were 37.50% and 85.71%,respectively. Traditional Chinese medicine enema group was better than hormone therapy group(P < 0.05). The abdominal pain relief time of the two methods was not very different(P > 0.05). The treatment effects of Traditional Chinese medicine enema group with the effective rate 86.2% was better than 40%of hormone therapy group on positive occult blood. Conclusion: Chinese medicine Xianyuan Decoction gelata enema and hormones have a good curative effect on mild-to-moderate pain in children with abdominal type allergic purpura. However,hormone treatment has a better effect on severe abdominal pain. Traditional Chinese medicine enema treatment has a more significant effect than hormone treatment on patients with positive occult blood in lab tests