三九天不同强度穴位贴敷治疗变应性鼻炎的疗效观察

Clinical Study of Sanjiu Herbal Patch on Acupoints with Different Intensity on Persistent Allergic Rhinitis

目的观察基于三九天不同强度的穴位贴敷方案治疗变应性鼻炎的临床疗效。方法将180例变应性患者随机分为生姜组、蜂蜜组及安慰剂组,每组60例,均采用三九天灸方(穴取大椎、风门、肺俞等),生姜组及蜂蜜组分别以新鲜姜汁、蜂蜜调和中药方,安慰剂组采用蜂蜜调和小米粉进行穴位贴敷,每周1次,共4周。采用变应性鼻炎症状、体征积分评价患者治疗前后的评分情况,观察治疗前后的血清特异性(S-IgE)并随访半年观察临床疗效。结果生姜组、蜂蜜组与治疗前比较,症状积分、体征积分均明显降低(P<0.05);安慰剂组与与治疗前比较,差异无统计学意义(P>0.05);生姜组与蜂蜜组比较,生姜组积分变化更加明显(P<0.05);3组比较,生姜组、蜂蜜组症状及体征积分明显低于安慰剂组(P<0.01)。各组分别与同组治疗前IgE水平比较中,差异无统计学意义(P>0.05);生姜组、蜂蜜组与安慰剂组比较,治疗后生姜组、蜂蜜组IgE均稍低于安慰剂组,差异无统计学意义(P>0.05)。各组治疗4周后、随访半年后疗效比较,治疗4周、随访半年后,生姜组、蜂蜜组疗效均优于安慰剂组(P<0.05);生姜组与蜂蜜组比较,生姜组治疗后和半年随访的总有效率均优于蜂蜜组(P<0.05)。结论三九天穴位敷贴法是一种治疗变应性鼻炎的有效方法,生姜组、蜂蜜组均能改善变应性鼻炎患者的临床症状和体征,但强刺激组对患者症状和体征的改善更优。

Objective: To observe the clinical effect of Sanjiu herbal patch on acupoints with different intensity on persistent allergic rhinitis. Methods: 180 patients with AR were randomly divided into 3 groups,with 60 cases in each: the fresh ginger group,the honey group,and the placebo group. The fresh ginger group received fresh ginger juice mixed with Traditional Chinese medicine,the honey group honey mixed with Traditional Chinese medicine,placebo group honey mixed with millet flour. The treatment was given once a week,lasting for 4 weeks,and the clinical effects were detected in half a year′s follow-up. Results: Compared with before treatment,symptom scores and sign scores of the fresh ginger group and the honey group went down obviously,with statistical significance(P < 0.05). There was no significant difference before and after treatment in the placebo group(P >0.05). Compared with the honey group,the score change of the fresh ginger group was more obvious(P < 0.05).Symptom scores and sign scores in the fresh ginger group and the honey group were much lower than that of the placebo group(P < 0.01). There was no significant difference in the level of IgE before and after treatment in the same group(P > 0.05). The level of IgE in the fresh ginger group and the honey group were little lower than that of the placebo group,without statistical significance(P > 0.05). In half a year′s follow-up,the curative effects of the fresh ginger group and the honey group were better than that of the placebo group(P < 0.05),and the fresh ginger group was better than the honey group(P < 0.05). Conclusion: Sanjiu herb patch on acupoints with different intensity can improve symptoms and signs of AR patients,and strong stimulation acupoint is better than weak one.