分泌AFP肿瘤、分泌CEA肿瘤和卵巢癌的放射免疫显象

Radioimmunoimaging of AFP-producing Tumors, CEA-producing Tumors and Ovarian Cancers

放射免疫显象技术的出现,为肿瘤的诊断、定位、预后和疗效判断以及随访提供了新的手段,是一项很有发展前途的新技术。国外对其研究正方兴未艾,在国内,我们首先报道了分泌AFP肿瘤放射免疫显象。本研究报告I标记抗CEA单克隆抗体在移植人结肠癌裸鼠的体内定位,I标记抗AFP多克隆抗体、抗卵巢癌多克隆抗体和抗CEA单克隆抗体的临床应用。

131I-labeled antibodies, including polyclonal anti-AFP antibody, antibody to ovarian carcinoma and monoclonal antibody to CEA, were used to localize AFP-producing tumors, ovarian carcinoma and colon carcinoma.Forty-one cases were studied.(1)Thirteen patients received 131I-labeled anti-AFP IgG. Metastatic lesions were localized in 5 of 6 patients with metastatic endodermal sinus tumor confirmed by pathology.A negative result was found in 1 chronic hepatitis patient and an intrahepatic lesion was detected in 1 of 6 liver cancer patients with normal blood AFP level. (2) 25 patients received 131I-labeled antibody to ovarian carcinoma. Satisfactory tumor imaging was obtained in 4 patients with primary ovarian carcinoma. In 12 patients with recurrent ovarian carcinoma, location of metastatic lesions was found in 10. Suspicious and negative results were found respectively in the other 2 patients. No antibody localization was observed in 3 patients with benign tumors. (3) From three patients with colon carcinoma confirmed by surgery and pathology receiving 131I-labeled anti-CEA monoelonal antibody, metastatic lesion in one patient with a high level blood CEA was satisfactorily localized while negative and suspicious results were obtained respectively in 2 patients with normal blood CEA level.