山莨菪碱(654-2)抗休克作用的实验研究

Experimental Studies on Effect of Anisodamine (654-2) on Endotoxic Shock

以大肠杆菌内毒素复制小白鼠内毒素血症、大鼠和家兔内毒素休克模型,观察到山莨菪碱(654-2)对其均有明显的保护作用。654-2可明显抑制内毒素休克动物血浆β-g活性的增高,对肝溶酶体膜有稳定作用;在体外可抑制PMN聚集及β-g的释放。这些可能是654-2抗休克作用的部分环节。

Endotoxemia of mice and endotoxic shock of rats and rabbits were produced by intravenous injection of E.coli endotoxin. The antishock effect of anisodamine (654-2)and mechanism of its action were investigated. The results showed that anisodamine might play an antishock effect, stabilize lysosomal membrane of rat liver in vitro and inhibit β-glucuronidase (β-g) activity in plasma during shock. Anisodamine might also inhibit β-g release from zymosan-stimulated PMNs as well as PMN aggregation induced by activated complement. It is suggested that these effects of anisodamine may be involved in the mechanism of its antishock effect.