荷苞牡丹碱诱发实验性癫痫大鼠各脑区的代谢和血流

Studies on Glucose Metabolism and Local Cerebral Blood Flow in Bicuculline-induced Rat Epilepsy

静脉注射γ-氨基丁酸受体阻断剂荷苞牡丹碱(Bicuculline)诱发大鼠实验性癫痫,用碳^(14)2脱氧葡萄糖([~14C]2DG)和碳~14碘化安基比林([~14C]IAP)放射自显影法测定各脑区的葡萄糖摄取率和脑血流.实验结果提示:(1)荷苞牡丹碱诱发实验性癫痫时边缘系统的皮层下结构海马、杏仁核及锥体外系轴中的苍白球、黑质等脑区可能起重要作用.(2)海马区出现葡萄糖代谢与脑血流的明显不一致性,这一特征性变化在实验性癫痫发作中的地位值得进一步研究。

Seizures in 31 conscious rats were induced by i. v. administration of bicu-culline. Local cerebral blood flow and glucose metabolism were measured autor-adiographially with 14C-2 dexoxyglucose and 14C-iodoantipyrine respectively during the episode of Seizures. The experimental result showed that: 1) hip-pocampus and amygdala of limbic system, globus pallidus and substantia ni-gra of extrapryamidal system might play an important role in induction of seizures by bicuculline and 2) seizures could result in apparent mismatches between hippocampal glucose metabolism and blood flow. This paradoxical phenomenon deserves further study in the pathogenesis of experimemtal ep-ilepsy.