依那普利联合银杏达莫注射液治疗早期糖尿病肾病的临床疗效观察

Observation on curative effect of enalapril combined with Ginkgo Dipyridamole injection on early diabetic nephropathy

目的：探究依那普利联合银杏达莫注射液治疗早期糖尿病肾病的临床疗效。方法：选取我院2010年1月～2013年12月收治的早期糖尿病肾病患者64例，随机分为观察组和对照组，给予对照组患者降血糖治疗和每日两次、每次5mg的依那普利，观察组患者在对照组治疗的基础上静脉注射250ml生理盐水和20ml银杏达莫注射液，2个月1疗程，1疗程后比较两组患者的尿蛋白定量、肾功能、血糖、血脂及糖化学蛋白的变化。结果：一个疗程后，两组患者的尿蛋白定量、肾功能、血糖、血脂及糖化学蛋白等均有所降低，且观察组明显高于对照组，差异具有统计学意义（P<0.05）；观察组患者的总有效率为87.5%，明显高于对照组患者的62.5%，差异具有统计学意义（P<0.05）。结论：依那普利联合银杏达莫注射液治疗早期糖尿病肾病的临床疗效良好，可以显著降低血糖、尿蛋白定量及血脂等，显著改善肾功能，值得在临床上大力推广。

To explore the curative effect of enalapril combined with Ginkgo Dipyridamole injection on early diabetic nephropathy. Methods: 64 cases of patients with early diabetic nephropathy from January 2010 to December 2013 in our hospital were selected and randomly divided into an observation group and a control group. Patients in the control group were given hypoglycemic treatment, enalapriltwice per day, 5 mg each time, patients in the observation group were given 250 ml intravenous saline and 20 ml of ginkgo biloba injection on the basis of the treatment for the control group,, 2 months as a course.The quantity of urinary protein,, renal function, blood glucose, blood lipid and sugar chemical protein of two groups were compared after oe course. Results: After a period of treatment, The quantity of urinary protein,, renal function, blood glucose, blood lipid and sugar chemical protein were reduced, and the observation group was significantly better than the control group, and the difference was statistically significant (P<0.05); the total effective rate of the observation group was 87.5%, significantly higher than the control group 62.5% with statistically significant difference (P<0.05). Conclusion: Enalapril combined with Ginkgo Dipyridamole injection in the treatment of early diabetic nephropathy has good clinical curative effect , reduce glucoser, urine protein and blood lipid and improve renal function, which is worthy of promotion.