Nose-only cigarette smoke exposure plus airway lipopolysaccharide inhalation induced chronic obstructive pulmonary disease and associated pulmonary hypertension in mice

Objective To establish a mouse model of chronic obstructive pulmonary disease(COPD)and associated pulmonary hypertension(COPD-PH)induced by noseonly cigarette smoking exposure plus airway lipopolysaccharide(LPS)inhalation.Methods There were 24 male C57B6 mice divided into a control group and a