Bone morphogenetic protein-7 negatively regulates insulin signal transduction in C2C12 myotubes and Hep G2 hepatocytes

Objective To investigate the effects of bone morphogenetic protein-7(BMP7)on insulin signaling transduction in C2C12 myotubes and Hep G2 hepatocytes,and to study the underlying mechanisms preliminarily.Methods The C2C12 myotubes and Hep G2 cells were treated with BMP7 at different concentrations.The insulin