Apolipoprotein C Ⅲ promotes atherosclerosis by increasing oxidative stress and endoplasmic reticulum stress

Objective To construct the apolipoprotein CⅢ（Apo CⅢ）transgenic mice,and to hybridize with low density lipoprotein receptor（LDLR）knockout nice susceptible to atherosclerosisl;To obtain the Apo CⅢtransgene+LDLR defect(Apo CⅢ+LDLR-/-)mice model;