摘要
Objective To study the role and mechanism of sphingosine-phosphate(S1P)/sphingosine-1-phosphate receptor 1(S1P1)signal pathway during post conditioning of hypertrophic cardiomyocytes.Methods Neonatal rat cardiomyocytes were isolated and cultured,then stimulated by norepinephrine(NE)to induce cardiomyocytes hypertrophy.Using tri-gas incubator to create