Bufalin alleviates adriamycin- induced podocyte injury by up-regulating the expression of vitamin D receptor

Objective To investigate the role of vitamin D receptor（VDB）in the protection of bufalin on podocyte injury induced by adriamycin（ADR）.Methods（1）In vitro:the toxic effect of different concentrations of bufalin(10-9,10-8,10-7,10-6mol/L)on podocyte was evaluated by lactate dehydrogenase（LDH）test;Annexin V-FITC and RT-PCR were utilized for podocyte