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Effect of CHOP siRNA on mRNA expression of PERK-ATF4-CHOP pathway in diabetic peripheral neuropathy rats

Effect of CHOP siRNA on mRNA expression of PERK-ATF4-CHOP pathway in diabetic peripheral neuropathy rats
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摘要 Objective To investigate the effect of C/EBP homologous protein (CHOP) on mRNA expressions of RNA-dependent protein kinase-like ER kinase (PERK)-activating transcription factor 4 (ATF4)-C/EBP homologous protein (CHOP) pathway in diabetic peripheral neuropathy(DPN) rats. Methods 48 SD male rats werefed with high-fat diet combined with intraperitoneal injectionof streptozotocin to replicate DPN Model. Then allthe rats were divided into control group (Con),control +CHOP siRNA group ( Con + CHOPsiRNA ), Modelcontrol group (Mod) and CHOP siRNA group. Transfectionreagent and CHOP siRNA were intrathecally injected.
作者 YANG Xinwei 杨鑫伟(Sch TCM,Capital Med Univ)
机构地区 Sch TCM
出处 《China Medical Abstracts(Internal Medicine)》 2019年第2期86-87,共2页 中国医学文摘(内科学分册(英文版)
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