摘要
Objective To investigate the expression of MCT8,DCX,SHH and ARC /ARG3. 1 in brain neurons of neonatalrats exposed to thyroid dysfunction in uterus.Methods Wistar pregnant rats were randomly divided intocontrol group and experimental groups in which rats weredrunk water with 1, 3, or 5 ppm propylthiouracil(PTU). The thyroid function and morphological changesof PND1 and PND7 were detected. The expression ofMCT8,DCX,SHH,ARC /ARG3. 1 protein in cerebralcortex and hippocampus were detected by Western blot orimmunohistochemistry. Results (1) The levels of TT4decreased significantly in PND1 pups of PTU 3 ppm and5 ppm groups (P < 0. 05 or P < 0. 01). The TSH levelssignificantly increased while FT4 levels significantly decreasedin pups of PTU 5 ppm group on PND7 ( P <0. 05).
