Effect of obstructive sleep apnea on the severity of acute pulmonary thromboembolism

Objective To investigate the effect of obstructivesleep apnea (OSA) on the severity of acute pulmonarythromboembolism (PTE). Methods Clinical data of patientswith acute PTE and OSA who were admitted toAnzhen Hospital from January 2015 to December 2017were retrospectively analyzed in this study. According tothe apnea hypopnea index (AHI),patients were dividedinto AHI≤15 /h group and AHI > 15 /h group. The levelsof oxygen desaturation index (ODI),mean pulse oxygensaturation (MSO2),the lowest pulse oxygen saturation( LSaO2), oxygen saturation < 90% time ratio(Ts 90%), hemoglobin, hematocrit ( HCT ), bloodplatelet,mean platelet volume (MPV),platelet distributionwidth ( PDW),hypersensitive C-reactive protein(hsCRP),homocysteine ( HCY),prothrombin time,activated partial thromboplastin time (APTT),fibrinogen(FIB),D-dimer,fibrin degredation product (FDP),Btypenatriuretic peptide,cardiac troponin I ( cTnI),arterialpartial pressure of oxygen (PaO2),arterial partialpressure of carbon dioxide (PaCO2) were compared betweenAHI≤15 /h group and AHI > 15 /h group. Differencesin the severity of PTE between the two groups werecompared;binary Logistic regression model was used toanalyze the risk factors of acute PTE severity.