Prognostic significance of minimal residual disease detection after first induction treatment in adult acute lymphoblastic leukemia patients treated with autologous stem cell transplantation

Objective To investigate the prognostic significanceof detection of minimal residual disease after first inductiontreatment (MRD1) in adult acute lymphoblastic leukemia(ALL) patients treated with autologous stem celltransplantation (auto-HSCT). Methods The clinical dataof 87 ALL patients who underwent auto-HSCT duringFebruary 2006 to April 2017 with MRD1 detection databy flow cytometry were analyzed retrospectively. The relationshipbetween MRD1 and relapse and survival ofALL patients after auto-HSCT was studied. Results Of87 patients,26 (29. 9%) were MRD1 positive. The proportionof high-risk immunophenotype ( pro-B,pro-T,pre-T,mature T) was significantly higher in MRD1-positivepatients than that in MRD1 negative patients(34. 6% vs 14. 5%,P = 0. 038). There was no significantdifference between positive and negative MRD1 patientsof age,sex,lineage ( T /B),immunophenotype(standard risk /high risk),high white blood cell count(B-ALL > 30 × 109 /L or T-ALL > 100 × 109 /L),highriskchromosome /gene ratio,the time from first completeremission to transplantation and pre-treatment regimen.