Relationship between total cerebral small vessel disease burden and hemorrhagic transformation of acute ischemic stroke patients after intravenous thrombolysis

Objective To investigate the relationship betweentotal cerebral small vessel disease (CSVD) burden andintracranial hemorrhage transformation (HT) after intravenousthrombolysis in patients with acute ischemicstroke (AIS). Methods One hundred and fifty-four patientswho suffered from ischemic stroke within 4. 5 hoursof onset and received recombinant tissue plasminogen activatorthrombolytic therapy in the emergency green channelof the First Affiliated Hospital of Soochow Universityfrom August 2016 to January 2018 were enrolled. HT examinedby computed tomography scan within 24 hours afterthrombolysis was included. The magnetic resonanceimaging examination was performed within 48 hours. Thepatients were divided into two groups: HT group andcontrol group according to the presence or absence ofHT.