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胶质瘤中EGFR基因异常及其靶向性治疗研究进展 被引量：4

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摘要 胶质瘤的形成与发展是一个复杂的过程。其中癌基因EGFR的激活、过表达或扩增、重排,为形成恶性胶质瘤的重要分子途径之一。开展对EGFR的信号转导干预治疗的研究,包括反义核酸、酪氨酸激酶抑制剂、特异性抗EGFR单克隆抗体及RNA干涉等,对恶性胶质瘤的治疗具有重要意义。
作者 董伦 浦佩玉
机构地区 天津医科大学总医院神经外科
出处 《国外医学（遗传学分册）》 2004年第1期46-50,53,共6页 Foreign Medical Sciences(Section of Genetics )
关键词 胶质瘤 EGFR 基因异常 靶向性治疗 基因治疗 单克隆抗体 RNA干涉 表皮生长因子受体
分类号 R730.5 [医药卫生—肿瘤]
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国外医学（遗传学分册）
2004年 第1期

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