脂质体在鼻腔给药制剂中的应用

Discussion on the Application of Liposome in Nasal Drug Delivery System For

鼻腔黏膜上丰富的血管利于药物的吸收,鼻腔给药不仅可以治疗鼻腔局部疾病,还可发挥全身作用,具有能避免胃肠道降解和肝脏首过效应,生物利用度高、起效快等特点。脂质体是一类具有特殊性质的磷脂,已被广泛作为多种药物的载体用于鼻腔给药。本文通过对脂质体及鼻腔给药制剂的阐述,介绍了脂质体在鼻腔给药制剂中的应用和优势,即有效控制药物释放、提高生物利用度、增加药物疗效和稳定性、降低药物的毒性等。

The nasal mucosa rich vascular conducive to drug absorption,nasal administration can not only treat rhinal disease,can also play a systemic role,can avoid gastrointestinal degradation and hepatic first pass efect,high bioavailability, rapid onset. Liposome is a kind of special nature of the phospholipid. This article through to the liposomes and intranasal preparation of liposome, introduces the application and advantages in the nasal drug formulations,namely the effective control of drug release, improve the bioavailability,increase the drug efficacy and stability, reducing drug toxicity.