氟哌噻吨美利曲辛联合盐酸氟桂利嗪胶囊治疗偏头痛患者的效果观察

Observation of Flupentixol and Melitracen Combined with Flunarizine Hydrochloride Capsules Treatment effect in Patients with Migraine

目的探讨氟哌噻吨美利曲辛联合盐酸氟桂利嗪胶囊治疗偏头痛患者的治疗效果。方法将2013年10月至2014年10月我院所收治的120例偏头痛患者纳入研究,根据随机数字表法将其均分为对照A组、对照B组、对照C组与观察组各30例。对照A组服用盐酸氟桂利嗪胶囊和安慰剂,对照B组单纯给予盐酸氟桂利嗪胶囊,对照C组单纯给予氟哌噻吨美利曲辛,观察组则采取盐酸氟桂利嗪胶囊与氟哌噻吨美利曲辛联合治疗,观察用药期间4组患者治疗效果,统计药物相关不良反应。结果对照A、B组患者的治疗总有效率分别为73.3%、76.7%,明显高于对照C组的56.7%,组间差异具有统计学意义(P<0.05);观察组患者的治疗总有效率为93.3%,明显高于对照组(P<0.05)。4组患者不良反应情况无明显差异(P>0.05)。结论在偏头痛患者的预防和治疗用药中,联合盐酸氟桂利嗪胶囊与氟哌噻吨美利曲辛治疗可收到满意效果,与单用氟哌噻吨美利曲辛或盐酸氟桂利嗪胶囊相比疗效更优,且无严重不良反应。

Objective To investigate the Flupentixol and melitracen combined with Flunarizine Hydrochloride Capsules treatment of migraine patients.Methods October 2013 to 2014 October in our hospital treated 120 cases of migraine were included in the study,according to the random number table method,which were divided into control group A and control group B,control C group and observation group,30 cases in each group.In the control group treated with flunarizine hydrochloride capsules and placebo,control B group treated with flunarizine hydrochloride capsules,C control group only received droperidol thiadiazole melitracen,observation group take hydrochloric acid flunarizine capsules and droperidol thiadiazole melitracen combined treatment,observed during the treatment of 4 groups of patients treatment effect,the statistics on drug related adverse reactions.Results Control in the treatment of patients in group A and B,the total effective rate was 73.3%,76.7% and was significantly higher than that of the control group C of 56.7%,the difference between the two groups with statistical significance(P<0.05);effect of the treatment group,the total efficiency was 93.3%,which was significantly higher than that of the control group(P<0.05). There was no significant difference in adverse reactions between the 4 groups(P>0.05).Conclusion In patients with migraine prophylaxis and treatment, hydrochloride combined with flunarizine capsules and droperidol thiazide tons of beauty and deanxit treatment can be received satisfactory effect,and droperidol Chlorprothixene beauty and deanxit or hydrochloric acid flunarizine capsule compared curative effect better,and no serious adverse reactions.