女性青春期后痤疮患者血清性激素水平变化与发病的相关性

Serum sex hormone level of women after puberty acne patients and the correlation between sex hormone level and the pathogenesis of women after puberty acne

目的探讨女性青春期后痤疮患者血清性激素水平变化及其对痤疮发生、发展的影响。方法回顾性选取2015年3月至2016年3月于东莞市石碣医院皮肤科门诊就诊的女性青春期后痤疮患者资料40例为观察组,同期在本院体检的健康女性40例为对照组。两组均于月经期第5天采集空腹静脉血3 ml,采用放射免疫法检测两组血清黄体生成素(LH)、卵泡刺激素(FSH)、催乳素(PRL)、雌二醇(E2)、睾酮(T)、双氢睾酮(DHT)、游离睾酮(FT)、性激素结合球蛋白(SHBG)的表达情况。按照观察组患者痤疮严重程度分级,分析其分级与性激素表达水平的关系。结果观察组患者血清T、DHT、FT的表达水平明显高于对照组,差异均有统计学意义(均P<0.05);观察组患者血清SHBG明显低于对照组,差异有统计学意义(P<0.05),两组其余指标差异均无统计学意义(均P>0.05)。观察组患者按照痤疮严重程度分级,患者不同严重程度分级的性激素表达水平比较,差异无统计学意义(P>0.05)。结论性激素中雄激素T、DHT及SHBG表达含量与女性青春期后痤疮的发病密切相关,但与痤疮严重程度分级无明显相关性。

Objective To study the serum sex hormone level of women after puberty acne patients and the correlation between sex hormone level and the pathogenesis of women after puberty acne.Methods From March 2015 to March 2016,40 cases of women after puberty acne in Shijie hospital of Dongguan were collected as study group,in the same period in our hospital 40 cases of healthy women were collected as control group.3 ml venous blood of the two groups were collected at the fifth day of menses, and the expression of serum luteinizing hormone(LH),folliclestimulatinghormone(FSH),prolactin(PRL),estradiol(E2),testosterone(T),dihydrotestosterone(DHT),free testosterone(FT), sex hormone binding globulin(SHBG)of two groups were test by radioimmunoassay. According to the observation group of patients with acne severity classification, analysis of the relationship between the classification and sex hormone level.Results The expression of T,DHT,FT of study group were significantly higher than those of the control group(P<0.05),the expression of SHBG was significantly lower than that of the control group(P<0.05),and there were no significant difference of other indexs between two groups(P>0.05).According to severity classification, analyze the relationship between the expression level of sex hormones and severity classification,and found that there was no significant difference between the expression level of sex hormones and severity classification(P>0.05). Conclusion The expression levels of sex hormone androgen T,DHT and SHBG were closely related to the pathogenesis of women after puberty acne,but it had no obvious effects of relation with severity classification of acne.