强骨胶囊与骨瓜提取物注射液治疗骨质疏松性股骨骨折的价值分析

Value of Qianggu Capsule(强骨胶囊) and Gugua(骨瓜) Extract Injection in the Treatment of Osteoporotic Femoral Fracture

目的探讨强骨胶囊与骨瓜提取物注射液治疗骨质疏松性股骨骨折患者的价值。方法选取吉林省人民医院2016年9月至2018年1月收治的78例骨质疏松性股骨骨折患者作为研究对象,根据随机数字表法将其分为对照组与试验组,每组39例。其中,对照组患者单独采用骨瓜提取物注射液治疗,试验组患者联合骨瓜提取物注射液与强骨胶囊治疗,比较两组患者的临床治疗效果。结果试验组患者治疗的总有效率为94.8%,对照组为79.5%,组间比较差异有统计学意义(χ2=10.451,P=0.001)。比较骨痂骨密度(BMD)、股骨颈BMD、Harris髋关节功能评分量表(HHS)评分、视觉模拟评分法(VAS)评分及骨折愈合时间,试验组分别为(0.58±0.14)、(0.85±0.17)、(75.18±6.37)、(1.72±0.28)、(9.41±1.24),对照组分别为(0.51±0.09)、(0.74±0.19)、(67.92±6.23)、(2.83±1.16)、(10.93±1.57),差异均有统计学意义(t=2.626、2.694、5.129、5.808、4.744,P=0.010、0.008、0.000、0.000、0.000)。治疗前,两组患者骨代谢指标[钙(Ca)、磷(P)、碱性磷酸酶(ALP)、骨钙素(BGP)以及24 h尿标本中羟脯胺酸(HOP)]比较差异均无统计学意义(t=0.402、0.335、1.633、0.101、0.282,P=0.688、0.738、0.106、0.919、0.778);经不同方案治疗后,试验组患者各指标均显著优于对照组(t=2.088、2.170、3.321、2.254、3.865,P=0.040、0.033、0.001、0.027、0.000)。结论对骨质疏松性股骨骨折采用强骨胶囊与骨瓜提取物注射液联合治疗,疗效显著。

Objective To analyze the value of Qianggu capsule(强骨胶囊) and Gugua(骨瓜) extract injection in the treatment of osteoporotic femoral fracture. Methods A total of 78 patients with osteoporotic femoral fractures who admitted to Jilin Provincial People’s Hospital between September 2016 and January 2018 were divided into control group and experimental group based on the stochastic indicator method with 39 cases in each group. Among them, the control group was treated with Gugua extract injection alone, and the experimental group was treated with Gugua extract injection combined with Qianggu capsule. The clinical efficacy of the two groups was compared and analyzed. Results The total effective rate of the experimental group was 94. 8%, while that of the control group was 79.5%, The difference between the two groups was statistically significant(χ2 = 10.451, P=0.001). The BMD of callus, the BMD of the neck of the femur, HHS, VAS score and fracture healing time of 3 months were compared between two groups. The data in the experimental group were(0.58±0.14),(0.85±0.17),(75.18±6.37),(1.72±0.28) and(9.41±1.24), and that in the control group were(0.51±0.09),(0.74±0.19),(67.92±6.23),(2.83±1.16) and(10.93±1.57), which were statistically significant(t=2.626, 2.694, 5.129, 5.808, 4.744, P=0.010, 0.008, 0.000, 0.000, 0.000). There was no significant difference between the two groups of bone metabolism indexes(Ca, P, ALP, BGP, 24 h urine HOP) before treatment(t=0.402, 0.335, 1.633, 0.101, 0.282, t=0.688, 0.738, 0.106, 0.919, 0.778). After different treatments, the indexes of the experimental group were significantly superior to those of the control group(t=2. 088, 2.170, 3.321, 2.254, 3. 865, P=0.040, 0.033, 0.001, 0.027, 0.000). Conclusion Femoral fracture with osteoporosis can be treated by combination of Qianggu capsule and Gugua extract injection, which is of significant efficiency.