厄贝沙坦联合心宝丸治疗老年慢性心力衰竭合幵窦性心动过缓的临床效果

Clinical Effects of Irbesartan Combined with Xinbao Pills(心宝丸) in Treating Senile Chronic Heart Failure with Sinus Bradycardia

目的探讨厄贝沙坦联合心宝丸治疗老年慢性心力衰竭合并窦性心动过缓患者的临床效果。方法研究对象为抚顺矿务局总医院老年医学科2015年7月至2018年1月收治的86例慢性心力衰竭合并窦性心动过缓患者,将其采用随机数字表法分为对照组与观察组,每组43例。两组患者均采用硝酸酯类、利尿剂、地高辛等药物进行治疗。同时,对照组患者口服厄贝沙坦,观察组患者在对照组基础上联合心宝丸治疗。比较两组患者治疗前后心功能指标、血浆N末端脑钠肽原及临床疗效。结果治疗前,两组患者各心功能指标比较,差异均无统计学意义(均P>0.05);治疗后,观察组患者的每搏输出量、左心室射血分数、6 min步行试验结果明显高于对照组,左心室舒张末期内径、左心室收缩末期内径明显低于对照组,差异均有统计学意义(均P<0.05)。治疗前,两组患者血浆N末端脑钠肽原比较,差异无统计学意义(P>0.05);治疗后,观察组患者的血浆N末端脑钠肽原水平明显低于对照组,差异有统计学意义(P<0.05)。观察组患者治疗有效率为93.0%,对照组治疗有效率为76.8%,组间比较差异有统计学意义(P<0.05)。结论厄贝沙坦与心宝丸联合治疗慢性心力衰竭合并窦性心动过缓,能有效改善患者的心功能,疗效确切。

Objective To observe the clinical effect of irbesartan combined with Xinbao pills(心宝丸) in treating senile chronic heart failure with sinus bradycardia. Methods The study involved 86 patients with chronic heart failure complicated with sinus bradycardia who were admitted in General Hospital of Fushun Mining Bureau from July 2015 to January 2018. All patients were randomly divided into control group and observation group with 43 cases in each group, Nitrates, diuretics and digoxin were used in both groups.The control group was given irbesartan orally, while the observation group was treated with Xinbao pills on the basis of the control group. Both groups were treated for 12 weeks. Cardiac function indexes, BNP and Clinical efficacy was compared between the two groups. Results There was no significant difference in cardiac function indexes between the two groups before treatment(P>0.05). The results of stroke volume, ventricular ejection fraction and 6 min walking test in the observation group were significantly higher than those in the control group(P<0.05). The end diastolic diameter of left ventricle and end systolic diameter of left ventricle were significantly lower than those in the control group(P<0.05). There was no statistical significance of the plasma level of n-terminal brain natriuretic peptide in the two groups before treatment(P>0.05). After treatment, the plasma level of n-terminal brain natriuretic peptide in the observation group was significantly lower than that in the control group, and the difference was statistically significant(P<0.05). The effective rate of in observation group was 93.0%, while the effective rate of control group was 76.8%. The difference between the groups was statistically significant(P<0.05). Conclusion Irbesartan combined with Xinbao pills for the treatment of chronic heart failure with sinus bradycardia can effectively improve the cardiac function of patients with obvious curative effect.