中西药联合治疗精神分裂症患者的有效性和安全性分析

Analysis of the Efficacy and Safety of Chinese and Western Medicine in Treating Schizophrenia

目的探讨中西药联合治疗精神分裂症患者的有效性及安全性。方法将2015年6月至2017年5月云浮市(罗定)第三人民医院收治的90例精神分裂症患者作为研究对象,随机分为两组,每组45例,对照组患者单以西药治疗,观察组患者行中西联合用药,观察两组患者的临床疗效,比较其治疗前后精神症状及中医症候评分,分析临床用药安全性,统计治疗期间不良事件发生情况。结果观察组患者治疗的总有效率为95.6%,明显高于对照组的86.7%,差异有统计学意义(P<0.05);组间症状评分比较,治疗后观察组患者的中医症候、阴性及阳性症状评分均低于对照组,差异均有统计学意义(均P<0.05);组间用药安全性比较,观察组患者治疗期间不良事件发生率为6.7%,低于对照组的17.8%,差异有统计学意义(P<0.05)。结论奥氮平联合养心汤合甘麦大枣汤加减治疗精神分裂症临床效果理想,可有效改善患者的症状,且临床用药安全性高、不良反应少。

Objective To explore the efficacy and safety of Chinese and western medicine in the treatment of schizophrenia. Methods A total of 90 patients admitted to the Third People’s Hospital of Luoding City from June 2015 to May 2017 were randomly divided into two groups with 45 patients in each group. Patients in the control group were treated with western medicine alone, while patients in the observation group were treated with Chinese and western medicine. The difference in clinical efficacy between the two groups of schizophrenic patients was observed, the differences in psychiatric symptoms and TCM(traditional Chinese medicine) symptom scores before and after treatment were compared between the two groups, the safety of clinical medication was analyzed, and the occurrence of adverse events during treatment was counted. Results The total effective rate of treatment in the observation group was 95.6%, which was significantly higher than 86.7% in the control group, and the difference was statistically significant(P<0.05). After treatment, the scores of TCM symptoms, negative symptoms and positive symptoms in the observation group were lower than those in the control group, and the difference was statistically significant(P<0.05). The incidence of adverse events in the observation group was 6.7 %, which was lower than 17.8 % in the control group, and the difference was statistically significant(P<0.05). Conclusion Olanzapine combined with Yangxin Decoction(养心汤) and modified Ganmai Dazao Decoction(甘麦大枣汤) has ideal clinical effect in treating schizophrenia, and can effectively improve the symptoms of patients. It not only has ideal therapeutic effect and improved symptoms, but also has high clinical medication safety and less adverse reactions.