双歧三联活菌片联合蒙脱石散治疗儿童腹泻的临床疗效

Clinical Efficacy of Bifid Triple Viable Bacterial Tablets Combined with Montmorillonite Powder in the Treatment of Diarrhea in Children

目的探讨采取双歧三联活菌片联合蒙脱石散治疗儿童腹泻的效果。方法选取2016年8月至2017年8月于灯塔市中心医院治疗的腹泻患儿68例为研究对象,按随机数字表法分为对照组与观察组,每组34例。对照组患儿采用蒙脱石散治疗,观察组患儿采用双歧三联活菌片联合蒙脱石散治疗,比较两组患儿的疗效。结果观察组患儿的有效率为94.12%,明显优于对照组的82.35%,差异有统计学意义(P<0.05);观察组患儿大便性状复常时间、体温正常时间、粪便常规复常时间、呕吐消失时间、腹痛消失时间均明显短于对照组,差异均有统计学意义(均P<0.05);治疗前,两组患儿免疫球蛋白G、免疫球蛋白A及CD_4^+/CD_8^+水平比较,差异均无统计学意义(均P>0.05);治疗后,两组患儿上述指标均明显升高,而观察组患儿升高幅度更显著,与对照组比较差异均有统计学意义(均P<0.05)。结论双歧三联活菌片联合蒙脱石散治疗儿童腹泻的安全性高,效果明显。

Objective To investigate the efficacy of bifid triple viable bacterial tablets combined with montmorillonite powder in children with diarrhea. Methods A total of 68 children with diarrhea enrolled in Dengta Central Hospital from August 2016 to August 2017 were selected. They were randomly divided into the control group(n=34, treated with montmorillonite powder) and the observation group(n=34, treated with bifid triple viable bacterial tablets combined with montmorillonite powder). The clinical efficacy of the two groups were compared. Results The effective rate of the observation group was 94.12%, which was higher than 82.35% of the control group, and the difference was statistically significantly(P<0.05). The restoration time of shapes and properties of feces, the time of temperature normalization, the time of normalization of routine examination of feces, the time of disappearance of vomiting, and the time of disappearance of abdominal pain were shorter than those of the control group and the difference was statistically significant(P<0.05). Before treatment, there were no significant differences in the levels of immunoglobulin G(IgG), immunoglobulin A(IgA) and CD4+/CD8+ between the two groups(P>0.05). After treatment, the above indexes of both groups increased significantly, while the increase of the observation group was more obvious, and the difference was significant compared with the control group(P<0.05). Conclusion Bifid triple viable bacterial tablets combined with montmorillonite powder has good effects and high safety in the treatment of diarrhea in children.