苦参洗液联合甲硝唑对细菌性阴道病患者阴道微环境及阴道局部细胞免疫功能的影响

Effects of Kushen Lotion(苦参洗液) Combined with Metronidazole on Vaginal Microenvironment and Local Cellular Immune Function in Patients with Bacterial Vaginosis

目的探讨苦参洗液联合甲硝唑对细菌性阴道病(BV)患者阴道微环境及阴道局部细胞免疫功能的影响。方法选取2017年2月至2018年6月佛山市高明区人民医院妇产科门诊接收的158例BV患者作为研究对象,按照治疗方法不同分为对照组与观察组,每组79例,其中接受甲硝唑治疗为对照组,联合应用甲硝唑与苦参洗液治疗为观察组。比较两组患者阴道微环境、局部细胞免疫功能以及复发状况。结果治疗前,两组患者阴道p H值、菌群密集度以及菌群多样性比较差异均无统计学意义(均P>0.05);治疗后,观察组阴道pH值、菌群密集度以及菌群多样化改善程度均优于对照组(均P<0.05)。两组治疗前阴道局部免疫指标白细胞介素-4(IL-4)、白细胞介素-12(IL-12)以及γ-干扰素(IFN-γ)水平比较差异均无统计学意义(均P>0.05);治疗后,观察组免疫相关指标水平均低于对照组(均P<0.05),且观察组复发率低于对照组(P<0.05)。结论苦参洗液联合甲硝唑治疗BV,有利于改善患者阴道微循环及免疫功能,减少复发次数,促使患者恢复健康,确保女性身心健康。

Objective To explore the effects of Kushen lotion(苦参洗液) combined with metronidazole on vaginal microenvironment and vaginal cellular immune function in patients with bacterial vaginosis(BV). Methods A total of 158 cases of BV received in the gynecology and obstetrics clinic of Gaoming District People’s Hospital of Foshan City from February 2017 to June 2018 were selected as the research objects. They were divided into the control group and the observation group according to different treatment methods, with 79 cases in each group. Among them, metronidazole was used as the control group, and metronidazole and Kushen lotion(苦参洗液) were combined as the observation group. The vaginal microenvironment, local cellular immune function, and recurrence were compared between the two groups. Results Before treatment, there was no significant difference in vaginal pH,microbial density and microbial diversity between the two groups(P>0.05). After treatment, the improvement of the vaginal pH,microbial concentration and bacteria group diversity in the observation group was significantly better than that of the control group(P<0.05). There was no significant difference in the levels of interleukin-4(IL-4), interleukin-12(IL-12) and interferon-γ(IFN-γ)between the two groups before treatment(P>0.05). After, the level of immune-related indicators in the observation group was lower than that in the observation group were lower than the control group(P<0.05), and the recurrence rate of the observation group was lower than that of the control group(P<0.05). Conclusion Kushen lotion(苦参洗液) combined with metronidazole is effective in improving vaginal microcirculation and immune function, reducing the number of recurrences, promoting the recovery of health and ensuring women’s physical and mental health.