丙酸氟替卡松、布地奈德、丙酸倍氯米松吸入剂治疗咳嗽变异性哮喘患儿的效果比较

Effect of Fluticasone Propionate, Budesonide and Beclomethasone Propionate Inhalation on Children with Cough Variant Asthma

目的探讨丙酸氟替卡松、布地奈德、丙酸倍氯米松吸入剂治疗咳嗽变异性哮喘患儿的效果比较。方法选取大连市普兰店区第三人民医院2017年3月至2018年8月收治的120例咳嗽变异性哮喘患儿作为研究对象,按照随机数字表法分为3组,即对照1组给予丙酸氟替卡松吸入气雾剂治疗,对照2组给予给予丙酸倍氯米松气雾剂治疗,观察组给予布地奈德气雾剂治疗,比较3组患儿治疗后总有效率、咳嗽消失率、第1秒用力呼气容积(FEV1)、最大呼气中段流量(MMEF)。结果观察组总有效率与对照1、2组相比较差异无统计学意义(P>0.05)。治疗第1周、4周、8周及12周,观察组咳嗽消失率与对照1、2组比较差异均无统计学意义(均P>0.05)。治疗后,观察组患儿的FEV1、MMEF明显高于对照1、2组,差异均有统计学意义(均P<0.05)。结论丙酸氟替卡松、布地奈德、丙酸倍氯米松吸入剂治疗咳嗽变异性哮喘患儿均具有显著疗效,但布地奈德改善肺功能更加显著。

Objective To investigate the effect of fluticasone propionate, budesonide and beclomethasone propionate inhalation on children with cough variant asthma. Methods A total of 120 children with cough variant asthma admitted to the Third People’s Hospital of Pulandian District of Dalian from March 2017 to August 2018 were selected as the research objects. According to the random number table, they were divided into 3 groups: control group 1 was treated with fluticasone propionate inhalation aerosol;control group 2 was treated with beclomethasone propionate aerosol;observation group was treated with budesonide aerosol. Total effective rate, cough disappearance rate, forced expiratory volume in the first second(FEV1) and maximal mid-expiratory flow(MMEF) were compared among the 3 groups after treatment in children. Results There was no significant difference in total effective rate between the observation group and the control group 1 and 2(P>0.05). In the 1 st, 4 th, 8 th and 12 th weeks of treatment,there was no significant difference in the cough disappearance rate between the observation group and the control group 1 and 2(P>0.05). After treatment, FEV1 and MMEF in the observation group were significantly higher than those in the control group 1 and 2, with statistical significance(P<0.05). Conclusion Fluticasone propionate, budesonide and beclomethasone inhalation have significant effects in the treatment of children with cough variant asthma, but budesonide has improved lung function more significantly.