酮咯酸氨丁三醇联合间苯三酚治疗结石性肾绞痛的临床效果

Clinical Efficacy of Ketorolac Tromethamine Combined with Phloroglucinol in the Treatment of Calculous Renal Colic

目的探讨酮咯酸氨丁三醇与间苯三酚对结石性肾绞痛的镇痛效果。方法选取2017年2月至2018年9月东莞市大朗医院收治的150例结石性肾绞痛患者作为研究对象,随机分为对照组与观察组,各75例。对照组给予间苯三酚,观察组在对照组给药基础上联合酮咯酸氨丁三醇治疗,比较两组患者镇痛镇静效果及不良反应发生情况。结果观察组给药后1 h、2 h、4 h的视觉模拟评分法(VAS)评分与Ramsay评分显著低于对照组,差异均有统计学意义(均P<0.05),其余时间点比较差异均无统计学意义(均P>0.05);观察组患者镇痛过程中不良反应5例(6.67%)与对照组4例(5.33%),差异无统计学意义(P>0.05)。结论酮咯酸氨丁三醇联合间苯三酚用于结石性肾绞痛镇痛具有起效快、镇痛效果明显,且安全性高等优点。

Objective To explore the analgesic effects of ketorolac tromethamine and phloroglucinol on calculous renal colic.Methods A total of 150 patients with calculous renal colic admitted to Dalang Hospital of Dongguan City from February 2017 to September 2018 were selected as research objects and randomly divided into control group and observation group,with 75 cases in each group.The control group was treated with phloroglucinol,while the observation group was treated with ketorolac tromethamine on the basis of the control group.The analgesic and sedative effects and adverse reactions of the 2 groups were compared.Results The VAS scores and Ramsay scores of 1 h,2 h and 4 h of administration in the observation group were significantly lower than those in the control group,with statistically significant differences(P<0.05),and there were no statistically significant differences in the comparison during other time points(P>0.05).There were 5 cases of adverse reactions in the observation group(6.67%)and 4 cases in the control group(5.33%),with no statistically significant difference(P>0.05).Conclusion Ketorolac tromethamine combined with phloroglucinol has the advantages of rapid onset,obvious analgesic effect and high safety.