持续性静脉泵入咪达唑仑应用于小儿癫痫持续状态的效果观察

Efficacy Observation of Continuous Intravenous Pumping of Midazolam on Children with Status Epilepticus

目的探讨持续性静脉泵入咪达唑仑应用于小儿癫痫持续状态的效果。方法选取2017年2月至2019年2月花都区妇幼保健院收治的70例癫痫持续状态患儿作为研究对象,依据不同的就诊顺序将其分为对照组(n=31)与试验组(n=39),对照组施以常规治疗,试验组施以持续性静脉泵入咪达唑仑治疗,观察两组患儿的临床治疗有效率情况、不良反应发生情况、治疗前与治疗2周后平均发病持续时间与发病间隔时间情况及家长的满意度情况。结果治疗前,两组患儿的平均发病持续时间与发病间隔时间无差异(P>0.05);治疗2周后,试验组的平均发病持续时间明显较短,发病间隔时间明显较长,并且试验组的临床治疗有效率与家长的满意度明显较高,不良反应发生率明显较低,与对照组相比差异有统计学意义(P<0.05)。结论持续性静脉泵入咪达唑仑应用于小儿癫痫持续状态的治疗具有显著的临床效果。

Objective To explore the efficacy of continuous intravenous pumping of midazolam on children with status epilepticus.Methods A total of 70 children with status epilepticus who were admitted to the Maternal and Child Health Care Hospital of Huadu Disrtict from February 2017 to February 2019 were selected as research objects.They were divided into control group(n=31)and experimental group(n=39)according to different treatment order.The control group received routine treatment,and the experimental group received continuous intravenous pumping of midazolam.The total effective rate of clinical treatment,the incidence of adverse reactions,and the average duration of onset,the interval of onset and parental satisfaction of the 2 groups before the treatment and after 2-week treatment were observed.Results Before the treatment,there was no difference between the average duration of onset and the interval between the 2 groups(P>0.05).After 2 weeks of treatment,the average duration of onset was significantly shorter in the experimental group,and the interval of onset was significantly longer.The total effective rate of clinical treatment and the satisfaction of parents in the experimental group were significantly higher,and the incidence of adverse reactions was significantly lower.The difference was significant compared with the control group(P<0.05).Conclusion Continuous intravenous pumping of midazolam has a significant clinical effect in the treatment of children with status epilepticus.