枸橼酸咖啡因联合经鼻持续气道正压通气治疗早产儿呼吸窘迫综合征的临床疗效

Clinical Efficacy of Caffeine Citrate Combined with Nasal Continuous Positive Airway Pressure Ventilation in the Treatment of Respiratory Distress Syndrome in Premature Infants

目的探讨枸橼酸咖啡因联合经鼻持续气道正压通气(NCPAP)治疗早产儿呼吸窘迫综合征(RDS)的临床疗效。方法将2017年1月至2018年12月就诊于彭湃纪念医院的86例早产儿RDS患儿作为研究对象,按随机数字表法分为两组,各43例。对照组行NCPAP治疗,观察组联合枸橼酸咖啡治疗。比较两组患儿呼吸机使用时间、呼吸暂停发作频率、住院时间、血气指标、不良反应发生情况。结果观察组呼吸机使用时间、住院时间短于对照组,呼吸暂停发作频率低于对照组,差异均有统计学意义(均P<0.05);治疗后观察组二氧化碳分压低于对照组,氧分压、血氧饱和度高于对照组,差异均有统计学意义(均P<0.05);观察组喂养不耐受、心动过速、烦躁不安、电解质紊乱发生率均低于对照组,差异均有统计学意义(均P<0.05)。结论 NCPAP联合枸橼酸咖啡因治疗早产儿RDS减少呼吸暂停发作频率,缩短治疗时间,改善血气指标,减少不良反应发生,安全性较高。

Objective To explore the clinical efficacy of caffeine citrate combined with nasal continuous positive airway pressure(NCPAP)in the treatment of respiratory distress syndrome(RDS)in premature infants.Methods According to the random number table method,86 cases of premature infants with RDS who visited Pengpai Memorial Hospital from January 2017 to December 2018 were divided into 2 groups,with 43 cases in each group.The control group was treated with NCPAP,while the observation group was treated with NCPAP combined with caffeine citrate.Duration of ventilator use,frequency of apnea episodes,length of hospital stay,blood gas indexes and adverse reactions were compared between the 2 groups.Results The duration of ventilator use and the length of hospital stay in the observation group were shorter than those in the control group,and the frequency of apnea episodes was lower than that in the control group,with statistically significant differences(P<0.05).After the treatment,the partial pressure of carbon dioxide in the observation group was lower than that in the control group,and the oxygen partial pressure and the blood oxygen saturation were higher than those in the control group,with statistically significant differences(P<0.05).The incidence of feeding intolerance,tachycardia,dysphoria and electrolyte disturbance in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion The combination of NCPAP and caffeine citrate in the treatment of premature infants with RDS can reduce the frequency of apnea episodes,shorten the treatment time,improve blood gas indexes,reduce adverse reactions,and have high safety.