胰岛素联合达格列净治疗2型糖尿病患者的临床疗效

Clinical Efficacy of Insulin Combined with Dapagliflozin in the Treatment of Patients with Type 2Diabetes Mellitus

目的探讨2型糖尿病患者采用胰岛素联合达格列净治疗的临床疗效。方法选取2017年2月至2019年2月葫芦岛市中心医院收治的2型糖尿病患者120例,以'入院顺序奇偶性'分组,分为对照组(接受胰岛素治疗,60例)和观察组(接受胰岛素+达格列净治疗,60例),比较两组患者血糖控制情况、每日胰岛素用量、血糖达标时间。结果观察组治疗后空腹血糖(FPG)、餐后2 h血糖(2hPBG)、糖化血红蛋白(HbA1c)水平、每日胰岛素用量均显著低于对照组,血糖达标时间显著短于对照组短,差异均有统计学意义(均P<0.05)。结论胰岛素+达格列净可显著降低2型糖尿病患者血糖水平,减少胰岛素用量,有助于血糖及早达标,疗效显著。

Objective To explore the clinical efficacy of insulin combined with dapagliflozin in the treatment of patients with type 2 diabetes mellitus.Methods A total of 120 patients with type 2 diabetes mellitus admitted to the Huludao Central Hospital from February 2017 to February 2019 were divided into control group(60 cases received insulin treatment)and observation group(60 cases received insulin plus dapagliflozin treatment),according to the odevity of admission order.Blood sugar control,daily insulin dosage and time of blood sugar reaching the standard were compared between the 2 groups.Results The levels of fasting blood glucose(FPG),2 h postprandial blood glucose(2 hPBG)and glycosylated hemoglobin(HbA1 c),and the daily insulin dosage in the observation group were significantly lower than those in the control group after the treatment,and the time of blood sugar reaching the standard was significantly shorter than that in the control group,with statistical significance(P<0.05).Conclusion Insulin plus dapagliflozin can significantly reduce the blood sugar level of patients with type 2 diabetes mellitus,reduce the dosage of insulin,and help blood sugar to reach the standard early,with significant efficacy.