血必净治疗重症肺炎患者的临床效果及其对炎症介质的影响

Clinical Efficacy of Xuebijing(血必净) in Patients with Severe Pneumonia and Its Effects on Inflammatory Mediators

目的探讨重症肺炎采用血必净治疗的有效性及其对炎症介质的影响。方法将鞍山市双山医院呼吸内科2017年9月至2019年2月收治的100例重症肺炎患者作为研究对象,按治疗方法不同分为对照组与血必净组,每组50例。比较两组患者临床疗效、体温恢复正常时间、白细胞数量恢复正常时间、机械通气时间、住院时间、不良反应发生情况以及治疗前后血清炎症介质水平、肺功能指标。结果血必净组临床疗效、体温恢复正常时间、白细胞数量恢复正常时间、机械通气时间、住院时间以及治疗后血清炎症介质水平、肺功能指标均优于对照组,差异均有统计学意义(均P<0.05)。两组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论重症肺炎患者在常规药物治疗基础上联合血必净治疗可有效改善患者临床症状,提高肺功能,降低炎症反应,临床治疗效果确切。

Objective To explore the effectiveness of Xuebijing in the treatment of severe pneumonia and its effects on inflammatory mediators.Methods A total of 100 patients with severe pneumonia admitted to the Department of Respiratory Medicine of Shuangshan Hospital in Anshan City from September 2017 to February 2019 were selected as research objects,and divided into control group and Xuebijing group according to different treatment methods,with 50 cases in each group.Clinical efficacy,recovery time of body temperature,recovery time of white blood cell count,mechanical ventilation time,hospitalization time,and incidence of adverse reactions,as well as serum inflammatory mediator levels and lung function indexes before and after the treatment were compared between the 2 groups.Results The clinical efficacy,recovery time of body temperature,recovery time of white blood cell count,mechanical ventilation time and hospitalization time,as well as the serum inflammatory mediator level and lung function index after the treatment in the Xuebijing group were better than those in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the 2 groups(P>0.05).Conclusions Clinical symptoms of severe pneumonia patients can be effectively improved by the combined treatment with Xuebijing on the basis of the routine treatment.It can improve pulmonary function and reduce inflammation,and the clinical efficacy is definite.